Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get Started
About our e-newsletters
- Free e-newsletters
- Mayo Clinic expertise
- We do not share your e-mail address
Housecall, our weekly general-interest e-newsletter, keeps you up to date on a wide variety of health topics with timely, reliable, practical information, recipes, blogs, questions and answers with Mayo Clinic experts and more. Our biweekly topic-specific e-newsletters also include blogs, questions and answers with Mayo Clinic experts, and other useful information that will help you manage your health.
Housecall Archives
Mayo Clinic Housecall
Stay up to date on the latest health information.
What you get
- Free weekly e-newsletter
- Mayo Clinic expertise
- Recipes, tools and other helpful information
- We do not share your e-mail address
Definition
By Mayo Clinic staffMyelofibrosis is a serious bone marrow disorder that disrupts your body's normal production of blood cells. The result is extensive scarring in your bone marrow, leading to severe anemia, weakness, fatigue, and often, an enlarged spleen and liver.
Myelofibrosis — also called agnogenic myeloid metaplasia or idiopathic myelofibrosis — can occur at any age, although it mainly develops after age 50.
Many people with myelofibrosis get progressively worse, and some eventually develop a serious form of leukemia. Yet it's also possible to have myelofibrosis and live symptom-free for years. Treatment for myelofibrosis, which focuses on relieving symptoms, can involve a variety of options.
- Tefferi A. Clinical manifestations and diagnosis of primary myelofibrosis (agnogenic myeloid metaplasia). http://www.uptodate.com/home/index.html. Accessed Oct. 14, 2008.
- Tefferi A. Prognosis and treatment of primary myelofibrosis (agnogenic myeloid metaplasia). http://www.uptodate.com/home/index.html. Accessed Oct. 14, 2008.
- Tefferi A. Pathogenic mechanisms in primary myelofibrosis (anogenic myeloid metaplasia). http://www.uptodate.com/home/index.html. Accessed Oct. 14, 2008.
- Cervantes F. Modern management of myelofibrosis. British Journal of Haemotology. 2005;128(5):583-92.
- Papageorgiou SG, et al. Allogeneic stem cell transplantation as treatment for myelofibrosis. Bone Marrow Transplant. 2006;38(11):721-727.
- Idiopathic myelofibrosis. Leukemia & Lymphoma Society. http://www.leukemia-lymphoma.org/attachments/National/br_1190656475.pdf. Accessed Oct. 14, 2008.
- Chronic idiopathic myelofibrosis. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/myeloproliferative/HealthProfessional/page5. Accessed Oct. 14, 2008.
- Myelofibrosis with myeloid metaplasia. MayoClinic.org. http://www.mayoclinic.org/myelofibrosis/treatment.html. Accessed Oct. 14, 2008.
- Reduced-intensity transplants. National Marrow Donor Program. http://www.marrow.org/PATIENT/Undrstnd_Disease_Treat/Undrstnd_Treat_Opt/Lrn_BMT_Cord/R_Intensity_Tx/index.html. Accessed Oct. 14, 2008.
