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  • With Mayo Clinic neurologist

    Jerry W. Swanson, M.D.

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Question

Nighttime headaches: How can I get relief?

I am awakened by nighttime headaches. What should I do?

Answer

from Jerry W. Swanson, M.D.

If you have nighttime headaches or headaches that awaken you from sleep, see your doctor for an accurate diagnosis. Treatment for nighttime headaches varies, depending on the type of headache and any underlying causes.

Hypnic — or "alarm clock" — headaches, which begin only during sleep, usually awaken a person at the same time every night. It's also possible to have daytime naps interrupted by hypnic headaches. Hypnic headaches are most common after age 50.

Possible treatments
The exact cause of hypnic headaches isn't known, but treatments that may provide relief for some individuals include:

  • Lithium (Lithobid) — a medication used to treat bipolar disorder
  • Indomethacin (Indocin) — a nonsteroidal anti-inflammatory medication
  • Melatonin — a hormone that helps control your natural sleep-wake cycle
  • Caffeine — taken as a tablet or beverage before bedtime

There are reports of small numbers of people whose headaches respond to other agents.

Next question
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References
  1. Goadsby PJ, et al. Headache. In: Fauci AS, et al. Harrison's Online. 17th ed. New York, N.Y.: The McGraw-Hill Companies; 2008. http://www.accessmedicine.com/content.aspx?aID=2890394. Accessed Nov. 8, 2010.
  2. De Simone R, et al. Hypnic headache: An update. Neurological Science. 2006;27:S144.
  3. Liang JF, et al. Clinical features, polysomnography and outcome in patients with hypnic headache. Cephalalgia. 2008;28:209.
  4. Garza I, et al. Symptomatic hypnic headache secondary to a nonfunctioning pituitary macroadenoma. Headache: The Journal of Head and Face Pain. 2009;49:470.
  5. Cutrer FM. Hypnic headache. http://www.uptodate.com/home/index.html. Accessed Nov. 9, 2010.
  6. Donnet A, et al. A consecutive series of 22 cases of hypnic headache in France. Cephalalgia. 2010;29:928.
  7. Lanteri-Minet M, et al. Hypnic headache. Current Pain and Headache Reports. 2010:14;309.
AN00992 Jan. 21, 2011

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