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Complications
By Mayo Clinic staffMany of the symptoms associated with Noonan syndrome are treated just as they would be for anyone else experiencing a health problem. Taken together though, the many problems this disorder can cause require coordinated management of various symptoms by your doctor and medical specialists who also may be part of your health care team.
Complications can arise that may require special attention, including:
- Developmental issues. If your child is affected developmentally, he or she may have difficulty with organization and spatial sense. Sometimes the developmental challenges are severe enough to require a special plan of action to address your child's learning and educational needs.
- Bleeding and bruising. Noonan syndrome can cause excessive bleeding and bruising. This can create problems during surgery or dental work. If excess bleeding and bruising affect you, avoid aspirin or aspirin-containing products because aspirin can thin your blood. Children in general need to avoid aspirin because of its association with Reye's syndrome.
- Complications from lymphatic problems. Sometimes fluid can collect in the cavity around the heart and lungs, requiring a chest tube to drain. If the draining is prolonged or needs to be repeated, this can sometimes result in weight loss or infection, and this in turn can lead to additional complications.
- Genital and urinary tract complications. Males may have a low sperm count and other fertility problems because of undescended testicles (cryptorchidism). Structural abnormalities in the kidneys may increase the rate of urinary tract infections.
- Noonan syndrome. Genetics Home Reference. http://ghr.nlm.nih.gov/condition=noonansyndrome. Accessed Oct. 22, 2008.
- Learning about Noonan syndrome. National Human Genome Research Institute. http://www.genome.gov/25521674. Accessed Oct. 22, 2008.
- Allanson JE. Noonan syndrome. American Journal of Medical Genetics. 2007;145C: 274-279.
- Allanson JE. Noonan syndrome. GeneReviews. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=noonan. Accessed Oct. 22, 2008.
- Lin AE. Adults with genetic syndromes and cardiovascular abnormalities: Clinical history and management. Genetics in Medicine. 2008;10(7):469-494.
- DeLuca A. NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome. The American Journal of Human Genetics. 2005;77(6):1092-1011.
- Tullu MS. Neurofibromatosis-Noonan syndrome or LEOPARD syndrome? A clinical dilemma. Journal of Postgraduate Medicine. 2000;46(2):98-100.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 23, 2008.
