CausesBy Mayo Clinic staff
The cause of oral lichen planus is unknown. T lymphocytes — certain white blood cells involved in inflammation — are normally active at the site of disease or injury and cause the lesions. Doctors and researchers don't know what prompts T lymphocytes to be activated in oral lichen planus. However, in some people, certain factors, such as those below, may trigger an inflammatory disorder.
- Hepatitis C infection and other types of liver disease
- Hepatitis B vaccine
- Allergy-causing agents (allergens), such as foods, dental materials or other substances
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others)
- Certain medications for heart disease, high blood pressure or arthritis
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- Gibson LE (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 8, 2013.
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