Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get Started
About our e-newsletters
- Free e-newsletters
- Mayo Clinic expertise
- We do not share your e-mail address
Housecall, our weekly general-interest e-newsletter, keeps you up to date on a wide variety of health topics with timely, reliable, practical information, recipes, blogs, questions and answers with Mayo Clinic experts and more. Our biweekly topic-specific e-newsletters also include blogs, questions and answers with Mayo Clinic experts, and other useful information that will help you manage your health.
Housecall Archives
Mayo Clinic Housecall
Stay up to date on the latest health information.
What you get
- Free weekly e-newsletter
- Mayo Clinic expertise
- Recipes, tools and other helpful information
- We do not share your e-mail address
Causes
By Mayo Clinic staffWomen have two ovaries, one on either side of the uterus. The ovaries — each about the size of an almond — produce eggs (ova) as well as the female sex hormones estrogen and progesterone. An ovarian tumor is a growth of abnormal cells that may be either noncancerous (benign) or cancerous (malignant). Although benign tumors are made up of abnormal cells, these cells don't spread to other body tissues (metastasize). Ovarian cancer cells metastasize in one of two ways. Generally, they spread directly to adjacent tissue or organs in the pelvis and abdomen. They can also spread through your bloodstream or lymph channels to other parts of your body.
Three basic types of ovarian tumors exist, designated by where they form in the ovary. They include:
- Epithelial tumors. About 85 to 90 percent of ovarian cancers develop in the epithelium, the thin layer of tissue that covers the ovaries, according to the American Cancer Society.
- Germ cell tumors. These tumors occur in the egg-producing cells of the ovary and generally occur in younger women.
- Stromal tumors. These tumors develop in the estrogen- and progesterone-producing tissue that holds the ovary together.
The exact cause of ovarian cancer remains unknown. Some researchers believe it has to do with the tissue-repair process that follows the monthly release of an egg through a tiny tear in an ovarian follicle (ovulation) during a woman's reproductive years. The formation and division of new cells at the rupture site may set up a situation in which genetic errors occur. Others propose that the increased hormone levels before and during ovulation may stimulate the growth of abnormal cells.
- Detailed guide: Ovarian cancer. American Cancer Society. http://documents.cancer.org/114.00/114.00.pdf. Accessed Aug. 20, 2008.
- Goff B. Early detection of ovarian cancer: Role of symptom recognition. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Chan LM, et al. Epithelial ovarian cancer: Clinical manifestations, diagnostic evaluation, staging, and histopathology. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Chan LM, et al. Epithelial ovarian cancer: Pathogenesis, epidemiology, and risk factors. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Zhou B, et al. Hormone replacement therapy and ovarian cancer risk: A meta-analysis. Gynecologic Oncology. 2008;108(3): 641-651
- Carlson KJ, et al. Patient information: Ovarian cancer screening. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Ovarian cancer: Treatment guidelines for patients. National Comprehensive Cancer Network and the American Cancer Society. http://www.cancer.org/downloads/CRI/NCCN_Ovarian_Cancer_2007.pdf. Accessed Aug. 19, 2008.
- Herzog TJ, et al. Patient information: Ovarian cancer treatment. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Benefits of good nutrition. American Cancer Society. http://www.cancer.org/docroot/MBC/content/MBC_6_2X_Benefits_of_nutrition_during_treatment.asp?sitearea=MBC. Accessed Aug. 24, 2008.
- Muto MG, et al. Risk reducing salpingo-oophorectomy in women at high risk of epithelial ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Aug. 19, 2008.
- Timothy Moynihan (expert review). Mayo Clinic, Rochester, Minn. Aug. 28, 2008.
