Risk factorsBy Mayo Clinic staff
Factors that increase the risk of developing OHSS include:
- Polycystic ovary syndrome — a common reproductive disorder that causes irregular menstrual periods, excess hair growth and unusual appearance of the ovaries on ultrasound examination
- Large number of follicles
- Young age
- Low body weight
- High or steeply increasing level of estradiol (estrogen) before an HCG shot
- Previous episodes of OHSS
- Migraine headache
- Becoming pregnant with multiple babies at one time
Young women with polycystic ovary syndrome who have many follicles are at highest risk of ovarian hyperstimulation syndrome. But knowing these risk factors doesn't predict exactly who will get OHSS, and sometimes the syndrome affects women with no risk factors.
- Van Voorhis BJ. Outcomes from assisted reproductive technology. Obstetrics & Gynecology. 2006;107:183.
- Manno M, et al. Ovarian hyperstimulation syndrome: The best approaches for prevention and treatment: A mini-review. Current Women's Health Reviews. 2007;3:49.
- Lobo RA. Infertility: Etiology, diagnostic evaluation, management, prognosis. In: Katz VL, et al. Comprehensive Gynecology. 5th ed. Philadelphia, Pa.: Mosby Elsevier; 2007. http://www.mdconsult.com/das/book/body/208746819-4/0/1524/0.html. Accessed Dec. 2, 2010.
- Practice Committee of the American Society for Reproductive Medicine. Ovarian hyperstimulation syndrome. Fertility and Sterility. 2006;86(suppl):S178.
- Insler V, et al. Pathogenesis of ovarian hyperstimulation syndrome. http://www.uptodate.com/home/index.html. Accessed Nov. 23, 2010.
- Insler V, et al. Classification and treatment of ovarian hyperstimulation syndrome. http://www.uptodate.com/home/index.html. Accessed Nov. 23, 2010.
- Luke B, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Fertility and Sterility. 2010;94:1399.
- Doody KJ. Treatment of the infertile couple. In: Schorge JO, et al. Williams Gynecology. New York, N.Y.: McGraw-Hill Medical; 2008. http://www.accessmedicine.com/content.aspx?aid=3158038. Accessed Dec. 6, 2010.
- Humaidan P, et al. Preventing ovarian hyperstimulation syndrome: Guidance for the clinician. Fertility and Sterility. 2010;94:389.
- Insler V, et al. Prevention of ovarian hyperstimulation syndrome. http://www.uptodate.com/home/index.html. Accessed Nov. 23, 2010.
- Coddington CC (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 22, 2010.