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Definition
By Mayo Clinic staff
Paget's (PAJ-its) disease of the breast is a rare form of breast cancer. Paget's disease of the breast starts on the nipple and extends to the dark circle of skin (areola) around the nipple. Paget's disease of the breast isn't related to Paget's disease of the bone, a metabolic bone disease.
Paget's disease of the breast occurs most often in women older than age 50. Most women with Paget's disease of the breast have underlying ductal breast cancer (in situ or, less commonly, invasive). Only in rare cases is the cancer confined to the nipple itself.
- Sabel MS, et al. Paget disease of the breast. http://www.uptodate.com/home/index.html. Accessed Aug. 4, 2010.
- Paget disease of the nipple: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Sites-Types/pagets-breast. Accessed Aug. 4, 2010.
- Abeloff MD, et al. Cancer of the breast. In: Abeloff MD, et al. Clinical Oncology. 4th ed. Philadelphia, Pa.: Elsevier Churchill Livingstone; 2008. http://www.mdconsult.com/das/book/body/100861143-2/0/1241/895.html?tocnode=51163917&fromURL=895.html#4-u1.0-B0-443-06629-9..50099-3--cesec126_4227. Accessed Aug. 4, 2010.
- Nicholson BT, et al. Nipple-areolar complex: normal anatomy and benign and malignant processes. RadioGraphics. 2009;29:509.
- Estimating breast cancer risk: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/estimating-breast-cancer-risk. Accessed July 30, 2008.
- What are the risk factors for breast cancer? American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_breast_cancer_5.asp?sitearea. Accessed Aug. 5, 2010.
- Morrogh M, et al. MRI identifies otherwise occult disease in select patients with Paget disease of the nipple. Journal of the American College of Surgeons. 2008;206:316.
- Caliskan M, et al. Paget's disease of the breast: The experience of the European institute of oncology and review of the literature. Breast Cancer Research and Treatment. http://www.springerlink.com/content/6270v27346461v08/. Accessed Aug. 5, 2010.
- Can breast cancer be prevented? American Cancer Society. http://www.cancer.org/Cancer/BreastCancer/OverviewGuide/breast-cancer-overview-prevention. Accessed Aug. 5, 2010.
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