Pancreas transplant

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Definition

By Mayo Clinic staff

A pancreas transplant is a surgical procedure to place a healthy pancreas from a donor into a person whose pancreas no longer functions properly. Almost all pancreas transplants are done to treat cases of type 1 diabetes.

Your pancreas is an organ that lies behind the lower part of your stomach. One of its main functions is to make insulin, a hormone that regulates the absorption of sugar (glucose) into your cells. Type 1 diabetes results when your pancreas can't make enough insulin, causing your blood sugar to rise to dangerous levels.

The side effects of a pancreas transplant can be significant, so pancreas transplant is typically reserved for those who have serious diabetes complications. A pancreas transplant is often done in conjunction with a kidney transplant.

References
  1. Humar A, et al. Transplantation. In: Brunicardi FC, et al. Schwartz's Principles of Surgery. 8th ed. New York, N.Y.: McGraw-Hill Companies; 2005. http://www.accessmedicine.com/content.aspx?aID=799511. Accessed June 24, 2009.
  2. Robertson RP. Patient selection for and immunologic issues related to kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed June 25, 2009.
  3. Pancreas Kaplan-Meier graft survival rates for transplants performed 1997-2004, by diagnosis. Organ Procurement and Transplantation Network. http://optn.transplant.hrsa.gov/latestData/rptStrat.asp. Accessed July 5, 2009.
  4. Facts about pancreas transplants. American Society of Transplantation. http://www.a-s-t.org/files/pdf/patient_education/english/AST-EdBroPANCREAS-ENG.pdf. Accessed June 30, 2009.
  5. American Diabetes Association position statement: Pancreas and islet transplantation in type 1 diabetes. Diabetes Care. 2006;29:935.
  6. Getting a kidney-pancreas transplant. National Kidney Foundation. http://www.kidney.org/atoz/atozItem.cfm?id=159. Accessed June 24, 2009.
  7. Robertson RP. Benefits and complications associated with kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed June 25, 2009.
  8. Larson-Wadd K, et al. Pancreas and islet cell transplantation. Anesthesiology Clinics of North America. 2004;22:663.
  9. Coping with the physical side effects of anti-rejection medications. American Society of Transplantation. http://www.healthytransplant.com/index.php?q=quality_of_life/coping_with_the_physical_side_effect_of_anti-rejection_medications. Accessed July 5, 2009.
  10. Punch JD. Organ transplantation. In: Doherty GM, et al. Current Surgical Diagnosis & Treatment. 12th ed. New York, N.Y.: McGraw-Hill Companies; 2006. http://www.accessmedicine.com/content.aspx?aID=2066708. Accessed June 24, 2009.
  11. Robertson RP. Pancreas and islet transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed June 25, 2009.
  12. OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, kidney-pancreas transplants — pancreas graft. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/809b_kp.htm. Accessed July 7, 2009.
  13. OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, pancreas after kidney (PAK) transplants. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/709_pak.htm. Accessed July 7, 2009.
  14. OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, pancreas transplant alone (PTA) transplants. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/609_pta.htm. Accessed July 7, 2009.

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Sept. 22, 2009

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