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By Mayo Clinic staffA pancreas transplant offers a potential cure for type 1 diabetes, but it's not a standard treatment. Often the side effects of the anti-rejection medications required after a pancreas transplant can be serious. But if you have any of the following, a pancreas transplant may be worthwhile:
- Type 1 diabetes that can't be controlled with standard treatment
- Frequent insulin reactions
- Consistently poor blood sugar control
- Severe kidney damage
Because type 2 diabetes occurs due to the body's inability to use insulin properly — and not because of a problem with insulin production in the pancreas — a pancreas transplant isn't a treatment option for most people with type 2 diabetes.
If you have severe kidney damage due to type 1 diabetes, a pancreas transplant may be combined with a kidney transplant or be done after successful kidney transplantation. This strategy aims to give you a healthy kidney and a pancreas that's unlikely to contribute to diabetes-related kidney damage in the future.
- Robertson RP. Patient selection for and immunologic issues relating to kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed May 28, 2011.
- Facts about pancreas transplants. American Society of Transplantation. http://www.a-s-t.org/files/pdf/patient_education/english/AST-EdBroPANCREAS-ENG.pdf. Accessed May 29, 2011.
- Klein C, et al. Benefits and complications associated with kidney-pancreas transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed May 28, 2011.
- Pancreas transplantation. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/treatment-and-care/transplantation/pancreas-transplantation.html. Accessed June 2, 2011.
- Robertson RP. Pancreas and islet transplantation in diabetes mellitus. http://www.uptodate.com/home/index.html. Accessed June 2, 2011.
- Humar A, et al. Transplantation. In: Brunicardi FC, et al. Schwartz's Principles of Surgery. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2010. http://www.accessmedicine.com/content.aspx?aid=5012706. Accessed May 28, 2011.
- Health after transplantation. American Society of Transplantation. http://www.healthytransplant.com/health_maintenance/health_after_transplantation.aspx. Accessed June 5, 2011.
- Preparing for the transplant. American Society of Transplantation. http://www.healthytransplant.com/health_maintenance/preparing_for_transplant.aspx. Accessed June 5, 2011.
- Kidney-pancreas transplant. National Kidney Foundation. http://www.kidney.org/atoz/content/kidpantx.cfm. Accessed June 5, 2011.
- OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, kidney-pancreas transplants — pancreas graft. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/809b_kp.htm. Accessed May 29, 2011.
- OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, pancreas after kidney (PAK) transplants. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/709_pak.htm. Accessed May 29, 2011.
- OPTN/SRTR annual report: Adjusted graft survival by year of transplant at 3 months, 1 year, 3 years, 5 years and 10 years, pancreas transplant alone (PTA) transplants. Scientific Registry of Transplant Recipients. http://www.ustransplant.org/annual_reports/current/609_pta.htm. Accessed May 29, 2011.
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