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Causes
By Mayo Clinic staff
As a baby develops in the womb, a vascular connection (ductus arteriosus) between two major blood vessels leading from the heart — the aorta and pulmonary artery — is a normal and necessary part of your baby's blood circulation while in the womb. The ductus arteriosus diverts blood from the lungs of the fetus while they aren't being used. The fetus receives oxygen from the mother's circulation. But, the ductus arteriosus is supposed to close within two or three days after birth once the newborn's heart adapts to life outside the womb. In premature infants, the connection often takes longer to close on its own. If the connection remains open, it's referred to as a patent ductus arteriosus.
The abnormal opening causes too much blood to circulate to the lungs and heart. If not treated, the blood pressure in the lungs may increase (pulmonary hypertension) and the heart may enlarge and weaken.
Congenital heart defects arise from problems early in the heart's development — but there's often no clear cause. Genetics and environmental factors may play a role.
- Patent ductus arteriosus. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/pda/. Accessed Nov. 9, 2011.
- Patent ductus arteriosus. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/pediatrics/congenital_cardiovascular_anomalies/patent_ductus_arteriosus_pda.html?qt=patent%20ductus%20arteriosus&alt=sh. Accessed Nov. 9, 2011.
- Schneider DJ, et al. Patent ductus arteriosus. Circulation. 2006;114:1873.
- Doyle T, et al. Clinical manifestations and diagnosis of patent ductus arteriosus. http://www.uptodate.com/home/index.html. Accessed Nov. 9, 2011.
- Phillips III JB, et al. Pathophysiology, clinical manifestations, and diagnosis of patent ductus arteriosus in premature infants. http://www.uptodate.com/home/index.html Accessed Nov. 9, 2011.
- Miyamoto SD, et al. Cardiovascular diseases. In: Hay WW, et al, eds. Current Diagnosis & Treatment: Pediatrics. 20th ed. New York, N.Y.: The McGraw-Hill Companies; 2011. http://www.accessmedicine.com/content.aspx?aID=6582787. Accessed November 13, 2011.
- Patent ductus arteriosus (PDA). American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/Patent-Ductus-Arteriosis-PDA_UCM_307032_Article.jsp#.Trsm4fJUFI4. Accessed Nov. 9, 2011.
- Warnes CA, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease). Journal of the American College of Cardiology. 2008;52:e143. Accessed Nov. 9, 2011.
- Clyburn RI, et al. Patent ductus arteriosus: Evidence for and against treatment. Journal of Pediatrics. 2007;150:216.
- Hammerman C, et al. Ductal closure with paracetamol: A surprising new approach to patent ductus arteriosus treatment. Pediatrics. In Press. Accessed Nov. 9, 2011.
- Preconception care questions and answers. U.S. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/preconception/QandA.htm. Accessed Nov. 14, 2011.
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