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Complications
By Mayo Clinic staffIn most people, a patent foramen ovale doesn't cause complications. The disorder has been associated with other conditions, such as stroke and migraine, but it's unknown whether or not patent foramen ovale is a potential cause of these conditions. Possible complications linked to patent foramen ovale include:
Stroke
Stroke is an interruption or reduction of blood supply to a part of the brain. Patent foramen ovale has been associated with an increased risk of stroke, especially strokes with no known cause that occur in people under 55 years old. Yet, most people with a patent foramen ovale will never have a stroke.
Migraine with aura
Migraines with aura are very painful headaches accompanied by sensations such as shimmering spots, blurred vision and blind spots. There is some evidence of a link between patent foramen ovale and migraine with aura, because some people's migraines get better after surgery to close a patent foramen ovale.
- Atrial septal defect (ASD). American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=11065. Accessed April 22, 2010.
- Bashore TM, et al. Heart disease. In: McPhee SJ, et al. Current Medical Diagnosis and Treatment 2010. 49th ed. New York, N.Y.: McGraw-Hill; 2010. http://www.accessmedicine.com/content.aspx?aID=3671. Accessed April 22, 2010.
- Slottow TL, et al. Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel meeting on patent foramen ovale closure devices. Circulation 2007;116:677.
- O'Gara PT, et al. Percutaneous device closure of patent foramen ovale for secondary stroke prevention: A call for completion of randomized clinical trials — A science advisory from the American Heart Association/American Stroke Association and the American College of Cardiology Foundation. Circulation. 2009;119:2743.
- Johansson MC, et al. The significance of patent foramen ovale: A current review of associated conditions and treatment. International Journal of Cardiology. 2009;134:17.
- Specific cardiac defects. In: Libby P, et al. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec197&displayedEid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec222&uniq=197042004&isbn=978-1-4160-4106-1&sid=987452515. Accessed April 22, 2010.
- Sommer RJ. Patent foramen ovale: Where are we in 2009? American Journal of Therapeutics. 2009;16:562.
- Rothrock JF. Patent foramen ovale (PFO) and migraine. Headache. 2008;48:1153.
- Meier B. Catheter-based closure of the patent foramen ovale. Circulation. 2009;120:1837.
- Grogan M (expert opinion). Mayo Clinic, Rochester, Minn. May 3, 2010
- Rosenow E (expert opinion). Mayo Clinic, Rochester, Minn. May 3, 2010.
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