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Pharmacogenomics: When drug treatment becomes personalized medicine
The field of pharmacogenomics promises to offer personalized medicine treatments based on your genetic profile. See if this promise is all hype or has potential.
By Mayo Clinic staffIn medicine, one size doesn't fit all. Two people who take the same cancer medication, for instance, may have very different responses. One may have severe, even life-threatening side effects, while the other experiences few if any side effects and seems to sail through treatment. Or, the drug may shrink a tumor in one person but not in another.
One major reason this difference happens is because people inherit variations in their genes. And even slight variations can affect how your body responds to certain medications. Pharmacogenomics is the science that studies, among other things, how individuals react to medications. Pharmacogenomics is sometimes described as "personalized" or "individualized" medicine because it offers the potential to recommend drug treatment based on your individual genetic background.
The field of pharmacogenomics is promising. In fact, a handful of tests are available that can detect some of these genetic variations and predict how you're likely to respond to certain medications. But pharmacogenomics still isn't widely used, so it's wise to educate yourself about just what pharmacogenomics can — and can't — offer.
How do genes influence response to medications?
Genes are segments of DNA, which are found in all of your cells. DNA is essentially a chemical operating system for your body, instructing it how to behave and interact on a cellular level. A basic gene can have many different forms. For instance, consider the gene that determines hair color. Normal variations of that gene determine specific hair color, such as brown or blond.
Similarly, your genes can determine how you react to a medication. You may have a genetic variation that makes the drug stay in your body longer than normal, causing serious side effects. Or you may have a variation that makes the medication less potent.
Scientists are trying to identify and record as many genetic variations as possible. Once a variation is identified, scientists might be able to match it up with a response to a particular medication and then develop a personalized approach to medicine.
Personalized medicine: Using pharmacogenomics
Say you're diagnosed with a certain disease, such as breast cancer, for which you must take medication. You and your doctor choose a medication based on standard drug therapy and dosing guidelines for that disease. Your doctor may also take into account such factors as your weight, age, medical history and even how any blood relatives have reacted to the same medication.
Despite all of that, neither you nor your doctor knows how you'll actually react to the medication. You may experience terrible side effects — or none at all. The medication may put your cancer into remission — or it may have no effect. Consequently, you may have to return to your doctor many times to adjust the dosage or to switch medications. This is how medication choices generally work today — it's often a matter of trial and error.
Pharmacogenomics could potentially speed up that process. Before you take a single dose of medication, you may be able to have a blood test to see which genetic variations you have. The test may show that you have a variation that's likely to adversely affect how you respond to the medication. So your doctor skips that drug and prescribes a different one, or your doctor alters the dose to match your body's genetics.
What are the benefits of pharmacogenomics?
Though current uses are limited, pharmacogenomics has the potential to offer many benefits.
Some of the potential benefits include:
- Making better medication choices. Each year, some 100,000 Americans die from adverse reactions to medications and more than 2 million are hospitalized. Medications generally undergo a rigorous review and testing process before being approved for sale. But there's still often no way to predict how a certain individual will react to a drug. So even if a medication appears safe for most people, some people may have a toxic reaction to it because of variations in their genes. Pharmacogenomics may be able to predict the people likely to have a bad reaction to a drug before they ever take it. It may also be able to predict if you'll respond well to a medication — whether your breast tumor will shrink, for example.
- Safer dosing options. As it stands now, the dosage of a medication either is a standard one-size-fits-all dose or is based on factors such as your weight and age. That might not be good enough, though. A standard dose may prove toxic to one person and not another, because of their genetic variations. Using pharmacogenomics, doctors may get around this problem by predicting which dose of medication is right for you, not just which particular medication is right. So you and your doctor may spend less time trying out various dosages to find one that works well, with the fewest side effects and most benefits for your condition.
- Improvements in drug development. Pharmaceutical companies often must spend years conducting research and clinical trials for a new drug before it goes to market. They have to test a drug in many people to ensure that it's safe and effective. Pharmacogenomics may help these companies better focus their drug testing. If companies know ahead of time that someone has a genetic variation that will cause a bad reaction to the drug or that will make the drug ineffective, those people can be excluded from the clinical trial. This may speed up the clinical trial process and better target people who can be helped by a certain medication.
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