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By Mayo Clinic staffYour doctor will want to know about your past reactions to penicillin and may examine you to identify or exclude other medical problems. He or she may also recommend a skin test. This test, in which your skin is injected with small amounts of penicillin, can determine your sensitivity to the drug. A small amount of penicillin is injected into the skin of your forearm or back. If you're allergic to the particular substance being tested, you develop a red, raised bump or reaction. Only specialized allergy centers perform skin tests for penicillin allergy.