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Complications
By Mayo Clinic staffIf your peripheral artery disease is caused by a buildup of plaques in your blood vessels (atherosclerosis), you're also at risk of developing:
- Critical limb ischemia. This condition begins as open sores that don't heal, an injury, or an infection of your feet or legs. Critical limb ischemia (CLI) occurs when such injuries or infections progress and can cause tissue death (gangrene), sometimes requiring amputation of the affected limb.
- Stroke and heart attack. The atherosclerosis that causes the signs and symptoms of peripheral artery disease isn't limited to your legs. Fat deposits also build up in arteries supplying your heart and brain.
References
- Peripheral artery disease. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec07/ch080/ch080f.html. Accessed Feb. 8, 2010.
- Peripheral artery disease. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/pad/pad_all.html. Accessed Feb. 6, 2010.
- Mohler III ER. Clinical features, diagnosis, and natural history of lower extremity peripheral arterial disease. http://www.uptodate.com/home/index.html. Accessed Jan. 29, 2010.
- Peripheral artery disease (PAD). Society for Vascular Surgery. http://www.vascularweb.org/patients/NorthPoint/Leg_Artery_Disease.html. Accessed Feb. 6, 2010.
- Hankey GJ. Medical treatment of peripheral artery disease. Journal of the American Medical Association. 2006;295:547.
- Peripheral vascular disease. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4692. Accessed Feb. 6, 2010.
- Hirsch AT, et al. ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease. Journal of the American College of Cardiology. 2006;47:e1.
- Langlois M, et al. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation. 2001;103:1863.
- Lane JS, et al. Nutrition impacts the prevalence of peripheral arterial disease in the United States. Journal of Vascular Surgery. 2008;48:897.
- Kuller LH. Does gingko biloba reduce the risk of cardiovascular events? Circulation: Cardiovascular Quality and Outcomes. 2010;3:41.
- Anderson CF (expert opinion). Mayo Clinic. Rochester, Minn. Feb. 9, 2010.
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