DefinitionBy Mayo Clinic staff
Peripheral neuropathy, a result of nerve damage, often causes weakness, numbness and pain, usually in your hands and feet, but it may also occur in other areas of your body.
People generally describe the pain of peripheral neuropathy as tingling or burning, while they may compare the loss of sensation to the feeling of wearing a thin stocking or glove.
Peripheral neuropathy can result from problems such as traumatic injuries, infections, metabolic problems and exposure to toxins. One of the most common causes is diabetes.
In many cases, peripheral neuropathy symptoms improve with time, especially if the condition is caused by an underlying condition that can be treated. A number of medications are used to reduce the painful symptoms of peripheral neuropathy.
- Peripheral neuropathy fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm. Accessed March 12, 2013.
- Peripheral neuropathy. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/neurologic_disorders/peripheral_nervous_system_and_motor_unit_disorders/peripheral_neuropathy.html?qt=peripheral%20neuropathy&alt=sh. Accessed March 12, 2013.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/content.aspx?aid=9148461. Accessed March 21, 2013.
- Ropper AH, et al. Adams & Victor's Principles of Neurology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=3641268&searchStr=peripheral+neuropathy#3641268. Accessed March 21, 2013.
- Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed March 19, 2013.
- Rutkove SB. Overview of polyneuropathy. http://www.uptodate.com/home. Accessed March 21, 2013.
- Feldman EL, et al. Treatment of diabetic neuropathy. http://www.uptodate.com/home. Accessed March 21, 2013.
- Neuropathic pain. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/neurologic_disorders/pain/neuropathic_pain.html?qt=neuropathic%20pain&alt=sh. Accessed March 22, 2013.
- Lewis R. Chronic inflammatory demyelinating polyneuropathy: Treatment and prognosis. http://www.uptodate.com/home. Accessed March 22, 2013.
- Fridey JL, et al. Prescription and technique of therapeutic plasma exchange. http://www.uptodate.com/home. Accessed March 22, 2013.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed March 22, 2013.
- Dietary supplement fact sheet: Vitamin B12. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Accessed March 22, 2013.
- Dyck, PJ (expert opinion). Mayo Clinic, Rochester, Minn. July 26, 2013.