SymptomsBy Mayo Clinic staff
The nerves of your peripheral nervous system send information from your brain and spinal cord (central nervous system) to all other parts of your body and back again.
Nerves that may be affected by peripheral neuropathy include:
- Sensory nerves that receive sensations such as heat, pain or touch
- Motor nerves that control how your muscles move
- Autonomic nerves that control functions such as blood pressure, heart rate, digestion and bladder function
Most commonly, peripheral neuropathy starts in the longest nerves, which are the nerves that reach to your toes. Symptoms vary, depending on which types of nerves are affected. Signs and symptoms may include:
- Gradual onset of numbness and tingling in your feet or hands, which may spread upward into your legs and arms
- Burning pain
- Sharp, jabbing or electric-like pain
- Extreme sensitivity to touch, even light touch
- Skin, hair or nail changes
- Lack of coordination
- Muscle weakness or paralysis if motor nerves are affected
- Heat intolerance if autonomic nerves are affected
- Bowel, bladder or digestive problems if autonomic nerves are affected
- Changes in blood pressure, causing dizziness or lightheadedness, if autonomic nerves are affected
Peripheral neuropathy may affect one nerve (mononeuropathy), two or more nerves in different areas (multiple mononeuropathy) or many nerves (polyneuropathy).
When to see a doctor
Seek medical care right away if you notice any unusual tingling, weakness or pain in your hands or feet. Early diagnosis and treatment offers the best chance for controlling your symptoms and preventing further damage to your peripheral nerves.
If your symptoms interfere with your sleep or you feel depressed, your doctor or pain specialist may be able to suggest treatments that can help.
- Peripheral neuropathy fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm. Accessed March 12, 2013.
- Peripheral neuropathy. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/neurologic_disorders/peripheral_nervous_system_and_motor_unit_disorders/peripheral_neuropathy.html?qt=peripheral%20neuropathy&alt=sh. Accessed March 12, 2013.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/content.aspx?aid=9148461. Accessed March 21, 2013.
- Ropper AH, et al. Adams & Victor's Principles of Neurology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=3641268&searchStr=peripheral+neuropathy#3641268. Accessed March 21, 2013.
- Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed March 19, 2013.
- Rutkove SB. Overview of polyneuropathy. http://www.uptodate.com/home. Accessed March 21, 2013.
- Feldman EL, et al. Treatment of diabetic neuropathy. http://www.uptodate.com/home. Accessed March 21, 2013.
- Neuropathic pain. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/neurologic_disorders/pain/neuropathic_pain.html?qt=neuropathic%20pain&alt=sh. Accessed March 22, 2013.
- Lewis R. Chronic inflammatory demyelinating polyneuropathy: Treatment and prognosis. http://www.uptodate.com/home. Accessed March 22, 2013.
- Fridey JL, et al. Prescription and technique of therapeutic plasma exchange. http://www.uptodate.com/home. Accessed March 22, 2013.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed March 22, 2013.
- Dietary supplement fact sheet: Vitamin B12. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Accessed March 22, 2013.
- Dyck, PJ (expert opinion). Mayo Clinic, Rochester, Minn. July 26, 2013.