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Treatments and drugs
By Mayo Clinic staffOne goal of treatment is to manage the condition causing your neuropathy. If the underlying cause is corrected, the neuropathy often improves on its own. Another goal of treatment is to relieve the painful symptoms. Many types of medications can be used to relieve the pain of peripheral neuropathy:
- Pain relievers. Mild symptoms may be relieved by over-the-counter pain medications. For more severe symptoms, your doctor may recommend prescription painkillers. Drugs containing opiates, such as codeine, can lead to dependence, constipation or sedation, so these drugs are generally prescribed only when other treatments fail.
- Anti-seizure medications. Drugs such as gabapentin (Neurontin), topiramate (Topamax), pregabalin (Lyrica), carbamazepine (Tegretol) and phenytoin (Dilantin) were originally developed to treat epilepsy. However, doctors often also prescribe them for nerve pain. Side effects may include drowsiness and dizziness.
- Lidocaine patch. This patch contains the topical anesthetic lidocaine. You apply it to the area where your pain is most severe, and you can use up to four patches a day to relieve pain. This treatment has almost no side effects except, for some people, a rash at the site of the patch.
- Antidepressants. Tricyclic antidepressant medications, such as amitriptyline and nortriptyline (Pamelor), were originally developed to treat depression. However, they have been found to help relieve pain by interfering with chemical processes in your brain and spinal cord that cause you to feel pain. The serotonin and norepinephrine reuptake inhibitor duloxetine (Cymbalta) also has proved effective for peripheral neuropathy caused by diabetes. Side effects may include nausea, drowsiness, dizziness, decreased appetite and constipation.
- Transcutaneous electrical nerve stimulation (TENS). In this therapy, adhesive electrodes are placed on the skin and a gentle electric current is delivered through the electrodes at varying frequencies. TENS has to be done frequently, but some people report this therapy improves their symptoms.
References
- Peripheral neuropathy fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm. Accessed Aug. 28, 2009.
- Peripheral nervous system and motor unit disorders. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec16/ch223/ch223a.html. Accessed Aug. 29, 2009.
- Ropper AH, et al. Diseases of the peripheral nerves. In: Ropper AH, et al. Adams and Victor's Principles of Neurology. 9th ed. New York, N.Y.: McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=3641268. Accessed Aug. 29, 2009.
- Feldman EL, et al. Treatment of diabetic neuropathy. http://www.uptodate.com/home/index.html. Accessed Aug. 18, 2009.
- Pai S. Peripheral neuropathy. In: Rakel D. Integrative Medicine. 2nd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/156944782-3/0/1494/62.html#4-u1.0-B978-1-4160-2954-0..50019-3--cesec2_528. Accessed Aug. 29, 2009.
- Dietary supplement fact sheet: Vitamin B12. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/vitaminb12.asp. Accessed Aug. 28, 2009.
