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Causes

By Mayo Clinic staff

An allergic reaction is somewhat like a case of mistaken identity within your body's immune system. Normally, your immune system generates antibodies to protect your body against bacteria, viruses or toxic substances.

If you have a pet allergy, your body generates an allergy-causing antibody to a protein found either in an animal's skin cells, saliva or urine. In other words, your immune system mistakenly identified this protein as something that could harm you. Once your body has developed an allergy-causing antibody to a particular agent (allergen) — in this case, an animal protein — your immune system will be sensitive to it. When you inhale the allergen or come into contact with it, your immune system responds and produces an inflammatory response in your nasal passages or lungs.

A pet allergen can cause two kinds of immune system responses in the airways of your lungs. An allergen can prompt inflammation in air passages. Therefore, prolonged or regular exposure to the allergen can cause the ongoing (chronic) inflammation associated with asthma. Exposure to an allergen also may cause sudden, severe constriction of air passages (bronchospasms).

Cats and dogs
Allergens from cats and dogs are found in skin cells the animals shed (dander), in saliva and on hairs. Dander is a particular problem because it is very small and can remain airborne for long periods of time with the slightest bit of air circulation. It also collects easily in upholstered furniture and sticks to your clothes.

Pet saliva can stick to carpets, bedding, furniture and clothing. Dried saliva can become airborne.

Some breeds of dogs are considered "hypoallergenic," or less likely to trigger allergies, because they don't shed fur. While the absence of shed fur may reduce exposure to dog allergens, a person allergic to dogs would still be allergic to nonshedding breeds.

Rodents and rabbits
Rodent pets include mice, gerbils, hamsters and guinea pigs. Allergens from rodents are usually present in hair, dander, saliva and urine. Dust from litter or sawdust in the bottom of cages may contribute to airborne allergens from rodents.

Rabbit allergens are present in dander, hair and saliva.

Other pets
Pet allergy is rarely caused by animals that don't have fur, such as birds, fish and reptiles.

References
  1. Ferguson BJ. Environmental controls of allergies. Otolaryngology Clinics of North America. 2008;41(2):411-417,viii-ix.
  2. German JA, et al. Environmental control of allergic diseases. American Family Physician. 2002;66(3):421-426.
  3. Spitzauer S. Allergy to mammalian proteins: At the borderline between foreign and self? International Archives of Allergy and Immunology. 1999;120(4):259-269.
  4. Airborne Allergens: Something in the Air. U.S. Department of Health and Human Services. Bethesda, Md.: National Institute of Allergy and Infectious Diseases; 2003.
  5. Fletcher R. Patient information: Rhinitis. http://www.uptodate.com/home/index.html. Accessed July 24, 2008.
  6. National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma - Summary Report 2007. Bethesda, Md.: National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/asthma/asthsumm.htm. Accessed Oct. 8, 2008.
  7. Tips to remember: Allergic skin conditions. American Academy of Allergy, Asthma & Immunology. http://www.aaaai.org/patients/publicedmat/tips/allergicskinconditions.stm. Accessed July 14, 2008.
  8. Platts-Mills T, et al. The role of allergens in asthma. American Family Physician. 2007;76(5):675-680.
  9. Tips to remember: Indoor allergens. American Academy of Allergy, Asthma & Immunology. http://www.aaaai.org/patients/publicedmat/tips/indoorallergens.stm. Accessed Oct. 7, 2008.
  10. deShazo R, et al. Patient information: Trigger avoidance in allergic rhinitis.  http://www.uptodate.com/home/index.html. Accessed July 24, 2008.
  11. Simpson A, et al. Pets and the development of allergic sensitization. Current Allergy and Asthma Reports. 2005;5(3):212-220.
  12. Takkouche B, et al. Exposure to furry pets and the risk of asthma and allergic rhinitis: A meta-analysis. Allergy. 2008;63(7):857-864.
  13. deShazo R, et al. Epidemiology and clinical manifestations of allergic rhinitis (rhinosinusitis). http:/www.uptodate.com/home/index.html. Accessed July 24, 2008.
  14. deShazo R, et al. Diagnosis of allergic rhinitis (rhinosinusitis). http://www.uptodate.com/home/index.html. Accessed July 27, 2008.
  15. Tips to remember: What is allergy testing? American Academy of Allergy, Asthma & Immunology. http://www.aaaai.org/patients/publicedmat/tips/whatisallergytesting.stm. Accessed Sept. 16, 2008.
  16. Tips to remember: What are "allergy shots"? American Academy of Allergy, Asthma & Immunology. http://www.aaaai.org/patients/publicedmat/tips/whatareallergyshots.stm. Accessed Sept. 16, 2008.

DS00859

Nov. 22, 2008

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