Phosphatidylserine supplements: Can they improve memory?

Can phosphatidylserine improve memory and cognitive function in people with Alzheimer's disease?

- Janet / Michigan

Mayo Clinic neuropsychologist Glenn Smith, Ph.D., and colleagues answer select questions from readers.

Answer

Phosphatidylserine is a dietary supplement that has received a great deal of interest as a potential treatment for Alzheimer's disease and other memory problems. Most studies involving phosphatidylserine indicate a benefit — improved cognitive abilities and behaviors. However, it seems to be most effective in people with the least severe symptoms.

It's not clear how phosphatidylserine improves memory. At least one study suggests that phosphatidylserine may lose its effectiveness after several months of use. But on the positive side, it has only a few, minor side effects, such as stomach upset.

Although phosphatidylserine seems to hold some promise as a potential treatment for people with Alzheimer's and other memory problems, it isn't the magic bullet sought by so many. As a supplement, phosphatidylserine is not required by the Food and Drug Administration to prove its potential benefits and risks. Be sure to consult your doctor before starting any supplement.