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Risk factors

By Mayo Clinic staff

Factors that increase your risk of developing premature ovarian failure include:

  • Age. The risk of ovarian failure rises as you age. The incidence of developing premature ovarian failure is about one in 250 by age 35 and one in 100 by age 40.
  • Family history. Having a family history of premature ovarian failure increases your risk of developing this disorder. About 10 percent of cases are familial.
Complications Causes

  • See Also

    • Hand Scheduled
    Section Focus
    Related Links
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    Children
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  • Menopause
References
  1. Cedars M, et al. Premature ovarian failure. Journal of Clinical Endocrinology and Metabolism. 2008;93:i.
  2. Do I have premature ovarian failure (POF)? National Institute of Child Health and Human Development. http://www.nichd.nih.gov/publications/pubs/pof/sub1.cfm#what. Accessed Dec. 1, 2008.
  3. Lobo RA. Menopause: Endocrinology, consequences of estrogen deficiency, effects of hormone replacement therapy, treatment regimens. In: Katz VL, et al. Comprehensive Gynecology. 5th ed. Philadelphia, Pa.: Mosby Elsevier; 2007. http://www.mdconsult.com/das/book/body/112160892-5/778264621/1524/277.html#4-u1.0-B978-0-323-02951-3..50045-5--cesec1_1347. Accessed Dec. 1, 2008.
  4. Welt CK. Pathogenesis and causes of spontaneous premature ovarian failure. http://www.uptodate.com/home/index.html. Accessed Nov. 25, 2008.
  5. Bulun SE, et al. The physiology and pathology of the female reproductive axis. In: Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/112160892-6/778264621/1555/106.html#4-u1.0-B978-1-4160-2911-3..50018-2--cesec91_1490. Accessed Dec. 1, 2008.
  6. Kalu E, et al. Spontaneous premature ovarian failure: Management challenges. Gynecological Endocrinology. 2008;24:273.
  7. Nelson LM, et al. Evaluation of spontaneous premature ovarian failure. http://www.uptodate.com/home/index.html. Accessed Nov. 25, 2008.
  8. Nelson LM, et al. Management of spontaneous premature ovarian failure. http://www.uptodate.com/home/index.html. Accessed Nov. 25, 2008.

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Dec. 31, 2008

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