DefinitionBy Mayo Clinic staff
Primary immunodeficiency disorders — also called primary immune disorders or primary immunodeficiency — weaken the immune system, allowing repeated infections and other health problems to occur more easily.
Many people with primary immunodeficiency are born missing some of the body's immune defenses, which leaves them more susceptible to germs that can cause infections.
Some forms of primary immunodeficiency are so mild they may go unnoticed for years. Other types of primary immunodeficiency are severe enough that they are discovered almost as soon as an affected baby is born.
Treatments can boost the immune system for many types of primary immunodeficiency disorders. Most people with primary immunodeficiency disorders lead relatively normal, productive lives. Children are able to attend school and play with friends.
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