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Symptoms
By Mayo Clinic staffOne of the most common signs of primary immunodeficiency is an increased susceptibility to infections. You may have infections that are more frequent, longer lasting or harder to treat than are the infections of someone with a normal immune system. You may also get infections that a person with a healthy immune system wouldn't get (called opportunistic infections). However, signs and symptoms differ depending on the particular type of disorder you have, and signs and symptoms also vary from person to person.
Signs and symptoms of primary immunodeficiency can include:
- Frequent and recurrent ear infections, pneumonia, meningitis, bronchitis, sinus infections or skin infections
- Blood infections
- Inflammation and infection of internal organs, such as the liver
- Autoimmune disorders, such as lupus, arthritis or type 1 diabetes
- Blood disorders, such as low platelet counts or anemia
- Digestive problems, such as cramping, loss of appetite, nausea and diarrhea
- Delayed growth and development
When to see a doctor
If you or your child has frequent, recurrent or severe infections, or infections that don't respond to treatment, talk to your doctor. While primary immune deficiencies are rare, early diagnosis and treatment can prevent infections that can cause long-term problems.
- Primary immunodeficiency. Eunice Kennedy Shriver National Institute of Child Health and Human Development. http://www.nichd.nih.gov/publications/pubs/primary_immuno.cfm. Accessed May 31, 2009.
- Introduction: Immunodeficiency disorders. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec13/ch164/ch164a.html?qt=primary immunodeficiency&alt=sh. Accessed May 31, 2009.
- 10 warning signs of primary immunodeficiency. Primary Immunodeficiency Resource Center of The Jeffrey Modell Foundation. Accessed May 31, 2009.
- Primary immunodeficiency diseases. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/patients/topicofthemonth/0407/. Accessed May 31, 2009.
- Specific medical therapy. In: Blaese R, et al. IDF Patient and Family Handbook for Primary Immunodeficiency Diseases. 4th ed. Towson, Md.: Immune Deficiency Foundation; 2007. Accessed June 3, 2009.
