Risk factorsBy Mayo Clinic staff
Risk factors for primary progressive aphasia include:
- Having learning disabilities. People with learning disabilities, particularly dyslexia, may be at higher risk of primary progressive aphasia, perhaps because both conditions involve using and understanding language.
- Having certain gene mutations. Rare gene mutations have been linked to the disorder. If several other members of your family have had primary progressive aphasia, you may be more likely to develop it.
- Ropper AH, et al. Adams & Victor's Principles of Neurology. 9th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=54. Accessed Oct. 12, 2012.
- Gorno-Tempini ML, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006.
- Harciarek M, et al. Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship. Neuropsychology Review. 2011;21:271.
- NINDS frontotemporal dementia information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/picks/picks.htm. Accessed Oct. 12, 2012.
- Rogalski E, et al. Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives. Archives of Neurology. 2008;65:244.
- Approach to the patient with aphasia. http://www.uptodate.com/index. Accessed Oct. 12, 2012.
- Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed Oct. 24, 2012.
- Aphasia. National Institute on Deafness and Other Communication Disorders. http://www.nidcd.nih.gov/health/voice/pages/aphasia.aspx. Accessed Oct. 29, 2012.
- Communicating with people who have aphasia. The National Aphasia Association. http://www.aphasia.org/Aphasia%20Facts/communicating_with_people_who_have_aphasia.html. Accessed Oct. 29, 2012.
- Caring for a person with a frontotemporal disorder. National Institute on Aging. http://www.nia.nih.gov/alzheimers/publication/frontotemporal-disorders-information-patients-families-and-caregivers/caring. Accessed Oct. 31, 2012.
- Treatment and management. National Institute on Aging. http://www.nia.nih.gov/alzheimers/publication/frontotemporal-disorders-information-patients-families-and-caregivers-0. Accessed Oct. 31, 2012.
- Boeve BF (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 20, 2012.
- Duffy JR (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 26, 2012.