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Complications
By Mayo Clinic staffComplications of primary sclerosing cholangitis may include:
- Liver disease and failure. Chronic inflammation of the bile ducts throughout your liver can lead to tissue scarring (cirrhosis), liver cell death and, eventually, the inability of your liver to function properly.
- Repeated infections. If scarring of the bile ducts impairs the flow of bile out of the liver, you may experience frequent infections in the bile ducts.
- Portal hypertension. Your portal vein is the major route for blood flowing from your digestive system into your liver. Portal hypertension refers to high blood pressure in this vein. Portal hypertension can cause fluid from the liver to leak into your abdominal cavity (ascites). It can also divert blood from the portal vein to other veins, causing these veins to become swollen (varices). Varices are weak veins and tend to bleed easily, which can be life-threatening.
- Thinning bones. People with primary sclerosing cholangitis may experience thinning bones (osteoporosis). Your doctor may recommend a bone density exam to test for osteoporosis every few years. Calcium and vitamin D supplements may be prescribed to help prevent bone loss.
- Bile duct cancer. If you have primary sclerosing cholangitis, you have an increased risk of developing cancer in the bile ducts or gallbladder.
- Colon cancer. People with primary sclerosing cholangitis associated with inflammatory bowel disease have an increased risk of colon cancer. If you've been diagnosed with primary sclerosing cholangitis, your doctor may recommend testing for inflammatory bowel disease, even if you have no signs or symptoms, since the risk of colon cancer is elevated if you have both diseases.
References
- Ross AS, et al. Sclerosing cholangitis and recurrent pyogenic cholangitis. In: Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed March 3, 2011.
- Diagnosis and management of primary sclerosing cholangitis. Alexandria, Va.: American Association for the Study of Liver Diseases. http://www.aasld.org/practiceguidelines/Documents/Practice%20Guidelines/PSC_2-2010.pdf. Accessed March 3, 2011.
- Lopez MJ, et al. Primary sclerosing cholangitis and primary biliary cirrhosis. The American College of Gastroenterology. http://www.acg.gi.org/patients/gihealth/sclerosing.asp. Accessed March 3, 2011.
- Primary sclerosing cholangitis. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/primarysclerosingcholangitis/index.htm. Accessed March 3, 2011.
- Liver health. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/liverhealth/. Accessed March 3, 2011.
- Mendes F, et al. Primary and sclerosing cholangitis: Overview and update. Nature Reviews Gastroenterology & Hepatology. 2010;7:611.
- Rosenthal TC, et al. Fatigue: An overview. American Family Physician. 2008;78:1173.
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