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    Gabrielle J. Melin, M.D.

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  • Depression blog

  • Jan. 27, 2009

    Pristiq: New antidepressant medication approved

    By Gabrielle J. Melin, M.D.

147 comments posted

Need more help?
  • National Suicide Prevention Lifeline
    1-800-273-TALK (8255)
  • Go to the nearest hospital or emergency room
  • Call your physician, health provider or clergy
  • National Alliance on Mental Illness
    www.nami.org
    1-800-950-NAMI (6264)

As I talked about last week, it takes quite a while for a new medication to be approved by the Food and Drug Administration (FDA). Additionally, medications can be granted additional indications (diseases the medication is approved to treat) over time. For instance, Rogaine was first developed for treating high blood pressure. The side effect of hair growth led to the additional indication of treatment for hair loss.

Pristiq (desvenlafaxine) was approved by the FDA in February of 2008 for the treatment of major depressive disorder in adults. Pristiq is not available in generic at this time and will not be for some time.

Pristiq works by preventing the reuptake of the serotonin and norepinephrine in the brain. We know that certain neurotransmitters such as norepinephrine, serotonin and dopamine are not in proper balance when a person is depressed. We don't routinely check neurotransmitter levels because we don't completely know what the levels mean. Someday checking these levels may be part of a depression screening.

Like many antidepressants, Pristiq can have side effects, which may include:

  • Nausea
  • Dizziness
  • Trouble sleeping
  • Hyperhidrosis (increased sweating)
  • Constipation
  • Fatigue
  • Decreased appetite
  • Anxiety
  • Sexual dysfunction in men

If you've been diagnosed with depression, Pristiq might be a good option if other medications haven't worked well. And, if you've taken Pristiq, please share your experiences.

147 comments posted

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Jan. 27, 2009

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