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Definition
By Mayo Clinic staff
Pseudomembranous colitis is inflammation of the colon that occurs in some people who have received antibiotics. Pseudomembranous colitis is sometimes called antibiotic-associated colitis or C. difficile colitis.
The inflammation in pseudomembranous colitis is almost always associated with an overgrowth of the bacterium Clostridium difficile (C. difficile), although in rare cases, other organisms can be involved.
Pseudomembranous colitis can cause you to experience painful, alarming symptoms and can even become life-threatening. However, treatment for most cases of pseudomembranous colitis is successful.
- Pseudomembranous colitis. In: Ferri FF. Ferri's Clinical Advisor 2011. Philadelphia, Pa.: Mosby; 2010. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&uniq=210978719. Accessed Aug. 5, 2010.
- Kelly CP, et al. Antibiotic-associated diarrhea, pseudomembranous enterocolitis and Clostridium difficile-associated diarrhea and colitis. In: Feldman M, et al. Sleisinger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa.: Saunders; 2010. http://www.mdconsult.com/book/player/linkTo?type=bookHome&isbn=978-1-4160-6189-2&eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&uniq=200844987-3. Accessed Aug. 5, 2010.
- Thielman NM, et al. Antibiotic-associated colitis. In: Mandell GL, et al. Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Churchill Livingstone; 2009. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-0-443-06839-3..X0001-X--TOP&isbn=978-0-443-06839-3&uniq=213242872. Accessed Aug. 5, 2010.
- Diarrhea. ADA Nutrition Care Manual. http://nutritioncaremanual.org/topic.cfm?ncm_heading=Nutrition%20Care&ncm_toc_id=19099. Accessed Aug. 6, 2010.
- Parkes GC, et al. The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea. Lancet Infectious Diseases. 2009;9:237.
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