3 imperatives to transform health care in America. You're invited to watch it live

Free

E-newsletter

Subscribe to Housecall

Our weekly general interest
e-newsletter keeps you up to date on a wide variety of health topics.

Sign up now

Causes

By Mayo Clinic staff

Controlling Your Arthritis

Subscribe to our Controlling Your Arthritis e-newsletter
for tips to manage arthritis.

Sign up now

Psoriatic arthritis occurs when your body's immune system begins to attack healthy cells and tissue. The abnormal immune response causes inflammation in your joints as well as overproduction of skin cells.

It's not entirely clear why the immune system turns on healthy tissue, but it seems likely that both genetic and environmental factors play a role. Many people with psoriatic arthritis have a family history of either psoriasis or psoriatic arthritis. Researchers have discovered certain genetic markers that appear to be associated with psoriatic arthritis.

Physical trauma or something in the environment — such as a viral or bacterial infection — may trigger psoriatic arthritis in people with an inherited tendency.

Risk factors Symptoms

  • See Also

    • Hand Scheduled
    Section Focus
  • Psoriasis

    • Related Links
    Related Guides
    Children
    Parent
References
  1. Fitzgerald O. Psoriatic arthritis. In: Firestein GS, et al. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa.: W.B. Saunders Co.; 2008. http://www.mdconsult.com/das/book/body/223128990-5/1070709009/1807/528.html#4-u1.0-B978-1-4160-3285-4..10072-5_2607. Accessed Oct. 19, 2010.
  2. Gladman DD. Clinical manifestations and diagnosis of psoriatic arthritis. http://www.uptodate.com/home/index.html. Accessed Oct. 19, 2010.
  3. Psoriatic arthritis. American College of Rheumatology. http://www.rheumatology.org/practice/clinical/patients/diseases_and_conditions/psoriaticarthritis.asp. Accessed Oct. 19, 2010.
  4. Kleinert S, et al. Psoriatic arthritis: Clinical spectrum and diagnostic procedures. Clinics in Dermatology. 2007;25:519.
  5. Gladman DD. Pathogenesis of psoriatic arthritis. http://www.uptodate.com/home/index.html. Accessed Oct. 19, 2010.
  6. Mercier LR. Arthritis, psoriatic. In: Ferri FF. Ferri's Clinical Advisor 2011. Philadelphia, Pa.: Mosby Elsevier; 2010. http://www.mdconsult.com/books/page.do?sid=1070709009&eid=4-u1.0-B978-0-323-07158-1..00003-1--s2020&isbn=978-0-323-07158-1&type=bookPage&sectionEid=4-u1.0-B978-0-323-07158-1..00003-1--s2020&uniqId=223128990-6. Accessed Oct. 19, 2010.
  7. Gladman DD. Treatment of psoriatic arthritis. http://www.uptodate.com/home/index.html. Accessed Oct. 19, 2010.
  8. Chang-Miller A (expert opinion). Mayo Clinic, Scottsdale, Ariz. Nov. 2, 2010.
DS00476 Dec. 9, 2010

© 1998-2013 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

  • Reprints
  • Print

  • Share on:

  • Email

Advertisement


Text Size: smaller largerlarger