ComplicationsBy Mayo Clinic staff
Complications of Rett syndrome include:
- Movement problems (motor dysfunction), such as irregular hand movements and difficulty walking
- Unusual sleep patterns — such as falling asleep during the day or waking up at night
- Difficulty eating, leading to poor nutrition and delayed growth
- Constipation, which can be a severe and long-term, ongoing problem
- Life-threatening heart rhythms (cardiac dysrhythmias)
- Thin, fragile bones prone to fractures
- Scoliosis (abnormal curvature of the spine), which may require surgery if it's severe
- Shortened life span — people with Rett syndrome don't live as long as most people because of heart problems and other health complications
- Schultz RJ, et al. Rett syndrome. http://www.uptodate.com/index. Accessed Aug. 27, 2012.
- Smeets EE, et al. Rett syndrome. Molecular Syndromology. 2012;2:113.
- Rett syndrome. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/rett-syndrome. Accessed Aug. 27, 2012.
- Disorders usually first diagnosed in infancy, childhood or adolescence. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed Aug. 28, 2012.
- Rett syndrome fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/rett/detail_rett.htm. Accessed Sept. 11, 2012.
- Neul JL, et al. Rett syndrome: Revised diagnostic criteria and nomenclature. Annals of Neurology. 2010;68:944.
- Lotan M. Alternative therapeutic intervention for individuals with Rett syndrome. The Scientific World Journal. 2007;29:698.
- Percy AK. Rett syndrome: Exploring the autism link. Archives of Neurology. 2011;68:985.