Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get StartedDefinition
By Mayo Clinic staffRheumatoid arthritis is a chronic inflammatory disorder that most typically affects the small joints in your hands and feet. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity.
An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues. In addition to causing joint problems, rheumatoid arthritis can also affect your whole body with fevers and fatigue.
Rheumatoid arthritis is two to three times more common in women than in men and generally occurs between the ages of 40 and 60. While there's no cure for rheumatoid arthritis, treatment options have expanded greatly in the past few decades.
- Rheumatoid arthritis. American College of Rheumatology. http://www.rheumatology.org/public/factsheets/diseases_and_conditions/ra.asp?aud=pat. Accessed Aug. 25, 2009.
- O'Dell JR. Rheumatoid arthritis. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/156141423-3/0/1492/1022.html#4-u1.0-B978-1-4160-2805-5..50290-1_12843. Accessed Aug. 25, 2009.
- Handout on health: Rheumatoid arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Rheumatic_Disease/default.asp. Accessed Aug. 25, 2009.
- Hunder GG. Mayo Clinic Straight Talk on Arthritis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2006.
- Rheumatoid arthritis and complementary and alternative medicine. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/RA/. Accessed Aug. 26, 2009.