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Causes
By Mayo Clinic staff
Rheumatoid arthritis occurs when your immune system attacks the synovium, the lining of the membranes that surround your joints. The resulting inflammation thickens the synovium, which can eventually invade and destroy the cartilage and bone within the joint. The tendons and ligaments that hold the joint together weaken and stretch. Gradually, the joint loses its shape and alignment.
Doctors don't know what starts this process, although a genetic component appears likely. While your genes don't actually cause rheumatoid arthritis, they can make you more susceptible to environmental factors — such as infection with certain viruses and bacteria — that may trigger the disease.
- Rheumatoid arthritis. American College of Rheumatology. http://www.rheumatology.org/public/factsheets/diseases_and_conditions/ra.asp?aud=pat. Accessed Aug. 25, 2009.
- O'Dell JR. Rheumatoid arthritis. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/156141423-3/0/1492/1022.html#4-u1.0-B978-1-4160-2805-5..50290-1_12843. Accessed Aug. 25, 2009.
- Handout on health: Rheumatoid arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Rheumatic_Disease/default.asp. Accessed Aug. 25, 2009.
- Hunder GG. Mayo Clinic Straight Talk on Arthritis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2006.
- Rheumatoid arthritis and complementary and alternative medicine. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/RA/. Accessed Aug. 26, 2009.
