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Symptoms
By Mayo Clinic staffSigns and symptoms of rheumatoid arthritis may include:
- Tender, warm, swollen joints
- Morning stiffness that may last for hours
- Firm bumps of tissue under the skin on your arms (rheumatoid nodules)
- Fatigue, fever and weight loss
Early rheumatoid arthritis tends to affect your smaller joints first — particularly the joints that attach your fingers to your hands and your toes to your feet. As the disease progresses, symptoms often spread to the knees, ankles, elbows, hips and shoulders. In most cases, symptoms occur in the same joints on both sides of your body.
Rheumatoid arthritis signs and symptoms may vary in severity and may even come and go. Periods of increased disease activity, called flares, alternate with periods of relative remission — when the swelling and pain fade or disappear. Over time, rheumatoid arthritis can cause joints to deform and shift out of place.
When to see a doctor
Make an appointment with your doctor if you have persistent discomfort and swelling in your joints.
- Handout on health: Rheumatoid arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Rheumatic_Disease/default.asp. Accessed Sept. 16, 2011.
- O'Dell JR. Rheumatoid arthritis. In: Goldman L, et al. Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed Sept. 16, 2011.
- Mercier LR. Rheumatoid arthritis. In: Ferri FF. Ferri's Clinical Advisor 2011: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&about=true&uniqId=230100505-53. Accessed Sept. 16, 2011.
- Schur PH, et al. General principles of management of rheumatoid arthritis. http://uptodate.com/home/index.html. Accessed Sept. 16, 2011.
- Stone JH. Tumor necrosis factor-alpha inhibitors: An overview of adverse effects. http://www.uptodate.com/home/index.html. Accessed Sept. 16, 2011.
- Kavanaugh A, et al. The locomotor system: Rheumatoid arthritis. In: Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4377-0986-5..C2009-0-38984-9--TOP&isbn=978-1-4377-0986-5&about=true&uniqId=236797353-5. Accessed Sept. 19, 2011.
- Schur PH, et al. Nonpharmacologic and preventive therapies of rheumatoid arthritis. http://www.uptodate.com/home/index.html. Accessed Sept. 19, 2011.
- Hints, tips, gadgets and resources. In: Lorig K, et al. The Arthritis Helpbook. 6th ed. Cambridge, Mass.: Da Capo Press; 2006. Accessed Sept. 19, 2011.
- Weisman MH. Total joint replacement for severe rheumatoid arthritis. http://www.uptodate.com/home/index.html. Accessed Sept. 19, 2011.
- Get the facts: Rheumatoid arthritis and CAM. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/RA/getthefacts.htm. Accessed Sept. 19, 2011.
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