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Causes
By Mayo Clinic staffIt's not clear what causes salivary gland cancer. Doctors know salivary gland cancer occurs when some cells in a salivary gland develop mutations in their DNA. The mutations allow the cells to grow and divide rapidly. The mutated cells continue living when other cells would die. The accumulating cells form a tumor that can invade nearby tissue. Cancerous cells can break off and spread (metastasize) to distant areas of the body.
Types of salivary gland cancer
Many different types of salivary gland cancer exist. Doctors classify salivary gland cancer based on the type of cells involved in the tumor. The type of salivary gland cancer you have helps your doctor determine which treatment options are best for you.
Types of salivary gland cancer include:
- Acinic cell carcinoma
- Adenocarcinoma
- Adenoid cystic carcinoma
- Clear cell carcinoma
- Malignant mixed tumor
- Mucoepidermoid carcinoma
- Oncocytic carcinoma
- Polymorphous low-grade adenocarcinoma
- Salivary duct carcinoma
- Squamous cell carcinoma
- Salivary gland cancer. American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_7x_CRC_Salivary_Gland_Cancer_PDF.asp. Accessed Jan. 20, 2010.
- Salivary gland cancer. Cancer.Net. http://www.cancer.net/patient/Cancer+Types/Salivary+Gland+Cancer. Accessed Jan. 29, 2010.
- Salivary gland cancer treatment (PDQ): Health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/salivarygland/healthprofessional/allpages/print. Accessed Jan. 20, 2010.
- Simental A, et al. Malignant neoplasms of the salivary glands. In: Cummings CW, et al. Otolaryngology: Head & Neck Surgery. 4th ed. Philadelphia, Pa.: Mosby; 2005. http://www.mdconsult.com/das/book/body/182968964-2/0/1263/0.html. Accessed Jan. 28, 2010.
- Quon H. Cancer of the head and neck. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:1177.
- Head and neck cancer: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/sites-types/head-and-neck. Accessed Jan. 20, 2010.
- Head and neck cancers. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/head-and-neck.pdf. Accessed Jan. 20, 2010.
- Jeannon JP, et al. Management of advanced parotid cancer: A systematic review. European Journal of Surgical Oncology. 2009;35:908.
- Dry mouth or xerostomia. Cancer.Net. http://www.cancer.net/patient/All+About+Cancer/Treating+Cancer/Managing+Side+Effects/Dry+Mouth+or+Xerostomia. Accessed Feb. 10, 2010.
- Cancer-related fatigue. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/fatigue.pdf. Accessed Feb. 10, 2010.
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