The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older):
Both oral (taken by mouth) and intravenous (injection) preparations of SAMe have been studied in clinical trials with some evidence of benefit for certain conditions. SAMe appears effective for osteoarthritis, and 600-1,200 milligrams has been taken daily in 1-3 divided doses for 10-84 days. Up to 1,600 milligrams has been taken for up to two weeks for the treatment of cholestasis. For depression, 800-1,600 milligrams daily was the most commonly used dosage range in clinical studies, for up to six weeks. For fibromyalgia, 400 milligrams twice daily has been used. For intrahepatic cholestasis of pregnancy, 500 milligrams given twice daily has been used. For general liver disease, 600-1,200 milligrams daily has also been used.
As an injection into the muscle, the most common dose for SAMe is 200-400 milligrams for 2-4 weeks. Both S-adenosyl-L-methionine 1,4-butanedisulphonate stable salt and disulfate-p-toluenesulfonate stable salt have been studied as injections. 500mg SAMe twice daily has also been delivered in a slow running infusion for twelve days followed by oral administration of 500mg twice daily. Injections should only be given under the supervision of a qualified healthcare professional, including a pharmacist.
Children (younger than 18 years):
There is no proven safe or effective dose for SAMe in children.