• Background
• Related terms
• Evidence
• Dosing
• Safety
• Methodology
• Selected references

• RSS Feeds

Selected references

1. Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur.Neuropsychopharmacol. 2005;15(5):533-543.
2. Binder T, Salaj P, Zima T, et al. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med 2006;34(5):383-91.
3. Bogarapu S, Bishop JR, Krueger CD, et al. Complementary medicines in pediatric bipolar disorder. Minerva Pediatr 2008 Feb;60(1):103-14.
4. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol. 1994;21(5):905-911.
5. Burrows RF, Clavisi O, Burrows E. Interventions for treating cholestasis in pregnancy (Cochrane Review). Cochrane Database Syst Rev 2001;4:CD000493.
6. Mato JM, Camara J, Fernandez de Paz, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30(6):1081-1089.
7. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 2007 May;45(5):1306-12.
8. Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-156.
9. Nicastri PL, Diaferia A, Tartagni M, et al. A randomised placebo-controlled trial of ursodeoxycholic acid and S- adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet.Gynaecol. 1998;105(11):1205-1207.
10. Ribalta J, Reyes H, Gonzalez MC, et al. S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo- controlled study with negative results. Hepatology 1991;13(6):1084-1089.
11. Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev 2006 Apr 19;(2):CD002235.
12. Roncaglia N, Locatelli A, Bellini P, et al. A randomized controlled trial of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of gestational cholestasis. Am J Obstet Gynecol 2000;182(1 pt 2):S167.
13. Roncaglia N, Locatelli A, Arreghini A, et al. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. BJOG 2004;111(1):17-21.
14. Tavoni A, Vitali C, Bombardieri S, et al. Evaluation of S-adenosylmethionine in primary fibromyalgia. A double- blind crossover study. Am J Med 11-20-1987;83(5A):107-110.
15. Volkmann H, Norregaard J, Jacobsen S, et al. Double-blind, placebo-controlled cross-over study of intravenous S- adenosyl-L-methionine in patients with fibromyalgia. Scand J Rheumatol. 1997;26(3):206-211.

Mayo Clinic Store

Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

• Try Mayo Clinic Health Letter FREE!
• Mayo Clinic Book of Alternative Medicine
• Mayo Clinic Five Steps to Controlling High Blood Pressure
• Reach out to Mayo Clinic pregnancy experts for confidential advice

The Mayo Clinic Diet — Eat well. Enjoy life. Lose weight.