Severe acute respiratory syndrome (SARS)

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Causes

By Mayo Clinic staff

SARS is caused by a strain of coronavirus, the same family of viruses that cause the common cold. Until now, these viruses have never been particularly virulent in humans, although they can cause severe disease in animals. For that reason, scientists originally thought that the SARS virus might have crossed from animals to humans. It now seems likely, however, that it evolved from one or more animal viruses into a completely new strain.

How SARS spreads
Most respiratory illnesses, including SARS, spread through droplets that enter the air when someone with the disease coughs, sneezes or talks. This type of transmission can occur in two ways:

  • Droplets. In droplet transmission, the infected particles are large and can travel only about three feet. To inhale them, you must be face to face with someone who's sick.
  • Airborne particles. Because airborne particles are much smaller than droplets, they travel farther and linger longer in the air. As a result, you can become infected even after the person who coughed or sneezed has left the room.

Most experts think SARS spreads mainly through face-to-face contact, but the virus also may be spread on contaminated objects, including doorknobs, telephones and elevator buttons.

References
  1. Hirsch MS, et al. Severe acute respiratory syndrome (SARS). http://www.uptodate.com/home/index.html. Accessed Nov. 17, 2008.
  2. Severe acute respiratory syndrome (SARS): Current SARS situation. Centers for Disease Control and Prevention. http://www.cdc.gov/nciDOD/sars/situation.htm. Accessed Nov. 17, 2008.
  3. Hui DS, et al. Current features, pathogenesis and immunobiology of severe acute respiratory syndrome. Current Opinion in Pulmonary Medicine. 2008;14:241.
  4. Severe acute respiratory syndrome: Frequently asked questions about SARS. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/sars/faq.htm. Accessed Nov. 18, 2008.
  5. Frequently asked questions on severe acute respiratory syndrome (SARS). World Health Organization. http://www.who.int/csr/sars/sarsfaq/en. Accessed Nov. 18, 2008.
  6. Clinical, epidemiologic, and virologic features of SARS-CoV. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/sars/guidance/core/app1.htm. Accessed Nov. 19, 2008.
  7. Tansey CM, et al. One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Archives of Internal Medicine. 2007;167:1312.
  8. Wong SS, et al. The management of coronavirus infections with particular reference to SARS. Journal of Antimicrobial Chemotherapy. 2008;62:437.
  9. Severe acute respiratory syndrome (SARS). Supplement F: Laboratory guidance. Diagnostic assays. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/sars/guidance/F/assays.htm. Accessed Nov. 19, 2008.
  10. Chu CM, et al. Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings. Thorax. 2004;59:252.
  11. Guidance about severe acute respiratory syndrome (SARS) for persons traveling to areas where SARS cases have been reported. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/sars/travel_advice.htm. Accessed Nov. 25, 2008.
  12. Stockman LJ, et al. Severe acute respiratory syndrome in children. The Pediatric Infectious Disease Journal. 2007;26:68.

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Jan. 6, 2009

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