CausesBy Mayo Clinic staff
Scleroderma results from an overproduction and accumulation of collagen in body tissues. Collagen is a fibrous type of protein that makes up your body's connective tissues, including your skin.
Although doctors aren't sure what prompts this abnormal collagen production, the body's immune system appears to play a role. For unknown reasons, the immune system turns against the body, producing inflammation and the overproduction of collagen.
- Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed April 4, 2013.
- Goldman L, et al. Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed April 4, 2013.
- Denton DP. Classification of scleroderma disorders. http://www.uptodate.com/home. Accessed April 4, 2013.
- Imboden JB, et al. Current Rheumatology Diagnosis & Treatment. 2nd ed. New York, N.Y.: The McGraw-Hill Companies; 2007. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=38. Accessed April 5, 2013.
- Osborn TG (expert opinion). Mayo Clinic, Rochester, Minn. April 8, 2013.
- Coping with scleroderma. Scleroderma Foundation. http://www.scleroderma.org/site/PageServer?pagename=patients_coping. Accessed April 5, 2013.