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    April Chang-Miller, M.D.

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Question

Sjogren's syndrome: Can it cause recurrent UTIs?

Since being diagnosed with Sjogren's syndrome last year, I've had three urinary tract infections. Is there any evidence that Sjogren's syndrome causes recurrent UTIs?

Answer

from April Chang-Miller, M.D.

No, but Sjogren's syndrome can cause symptoms that you might mistake for a urinary tract infection (UTI). Sjogren's syndrome is an autoimmune disorder in which the moisture-secreting glands of the eyes and mouth become inflamed, producing fewer tears and less saliva.

For women, Sjogren's syndrome can also cause vaginal dryness — which may result in discomfort during sexual intercourse and an increase in the risk of bacterial and fungal vaginal infections. Painful urination, a common symptom of UTIs, also can occur with vaginal infections.

Some women who have Sjogren's syndrome develop a condition called painful bladder syndrome, also known as interstitial cystitis. This condition causes symptoms similar to those of a urinary tract infection — urinary frequency, urgency and pain — without evidence of infection.

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References
  1. Naguwa S, et al. Sjogren's syndrome. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/206754856-8/1016326076/1492/1035.html#4-u1.0-B978-1-4160-2805-5..50294-9--cesec8_13058. Accessed June 22, 2010.
  2. Carsons S. Sjogren's syndrome. In: Firestein GS, et al. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa.: W.B. Saunders Co.; 2008. http://www.mdconsult.com/das/book/body/206754856-10/0/1807/500.html?tocnode=55733030&fromURL=500.html. Accessed June 22, 2010.
  3. Fox R, et al. Clinical manifestations of Sjogren's syndrome: Exocrine gland disease. http://www.uptodate.com/home/index.html. Accessed June 22, 2010.
  4. Fox R, et al. Clinical manifestations of Sjogren's syndrome: Extraglandular disease and prognosis. http://www.uptodate.com/home/index.html. Accessed June 22, 2010.
  5. Fitzgerald MP. Clinical features and diagnosis of painful bladder syndrome/interstitial cystitis. http://www.uptodate.com/home/index.html. Accessed June 22, 2010.
AN01893 Aug. 11, 2010

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