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Definition

By Mayo Clinic staff

Sjogren's (SHOW-grins) syndrome is a disorder of your immune system often defined by its two most common symptoms — dry eyes and a dry mouth.

Sjogren's syndrome often accompanies other autoimmune disorders — such as rheumatoid arthritis and lupus. These diseases are marked by inflammation of your connective tissues, and it's common for people with Sjogren's syndrome to also have a connective tissue disorder.

In Sjogren's syndrome, your immune system attacks healthy tissue. The mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first, resulting in decreased production of tears and saliva. The disease can damage other tissues as well.

Although you can develop Sjogren's syndrome at any age, most people are older than 40 at diagnosis. The condition is much more common in women. There's no cure, but treatments can relieve many symptoms.

Symptoms

DS00147

Aug. 6, 2007

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