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Definition

By Mayo Clinic staff

A skin biopsy removes cells or skin samples from the surface of your body. The sample taken from a skin biopsy is examined to provide information about your medical condition. A doctor uses a skin biopsy to diagnose or rule out certain skin conditions and diseases.

Three main types of skin biopsies are:

  • Shave biopsy. A doctor uses a tool similar to a razor to remove a small section of the top layers of skin (epidermis and a portion of the dermis).
  • Punch biopsy. A doctor uses a circular tool to remove a small section of skin including deeper layers (epidermis, dermis and superficial fat).
  • Excisional biopsy. A doctor uses a small knife (scalpel) to remove an entire lump or an area of abnormal skin, including a portion of normal skin down to or through the fatty layer of skin.
References
  1. Alguire PC, et al. Skin biopsy techniques. http://www.uptodate.com/home/index.html. Accessed Sept. 3, 2010.
  2. Dermatologic surgical procedures. In: Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Edinburgh; New York, N.Y.: Mosby Elsevier; 2010. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-0-7234-3541-9..X0001-6--TOP&isbn=978-0-7234-3541-9&uniq=208746819. Accessed Sept. 3, 2010.
  3. Armstrong CA. Examination of the skin and approach to diagnosing skin diseases. In: Goldman L, et al. Cecil medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed Sept. 3, 2010.
  4. Gibson LE (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 15, 2010.
MY00169 Oct. 19, 2010

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