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Definition

By Mayo Clinic staff

Small vessel disease, also known as coronary microvascular disease or small vessel heart disease, is a condition in which the small arteries in the heart become narrowed. Small vessel disease causes signs and symptoms of heart disease, such as chest pain (angina). Small vessel disease is usually diagnosed after a doctor checks for blockages in the main arteries of the heart that cause coronary artery disease, but finds little or no narrowing and your symptoms persist.

Although anyone can have small vessel disease, it's more common in women and in people who have diabetes. Small vessel disease is treatable, but can be difficult to detect.

References
  1. Mayo Clinic Health Letter. "Small vessel heart disease." October 2007. Vol. 25, No. 10, pp. 1-3.
  2. Mayo Clinic Women's HealthSource. "Small vessel heart disease." February 2008. Vol. 12, No. 2, pp. 1-2
  3. National Heart Lung and Blood Institute. "What is coronary microvascular disease?" September 2007. http://www.nhlbi.nih.gov/health/dci/Diseases/cmd/cmd_all.html (Viewed 4-22-08).
  4. Camici PC, Crea F. Coronary microvascular dysfunction. New England Journal of Medicine. 2007, Vol. 356, pp. 830-840.
  5. Playford DA, et al. Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes. Atherosclerosis. 2003, Vol. 168, pp. 169-179.
  6. Tiano L, et al. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. European Heart Journal. 2007, Vol. 28, pp. 2249-2255.
  7. Kurth T, et al. Migraine and ischaemic vascular events. Cephalalgia. 2007;27(8):965-975.
  8. Barrett BJ, et al. Differences in hormonal and renal vascular responses between normotensive patients with autosomal dominant polycystic kidney disease and unaffected family members. Kidney International. 1994;46(4):1118-1123.
  9. Schoenfeld Y, et al. Accelerated Atherosclerosis in Autoimmune Rheumatic Diseases. Circulation. 2005;112(21):3337-3347.

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Oct. 17, 2008

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