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Symptoms
By Mayo Clinic staffSmall vessel disease symptoms include:
- Chest pain, squeezing or discomfort over your central or left chest
- Chest pain associated with discomfort in your left arm or jaw
- Chest pain that worsens with activity, though eventually it may occur at rest too
- Neck, shoulder, upper back or abdominal discomfort
- Shortness of breath
- Unusual fatigue
- A lack of energy
If you've been treated for coronary artery disease with angioplasty and stents, and your signs and symptoms haven't gone away, you may also have small vessel disease.
When to see a doctor
It might be difficult to tell if your signs and symptoms are due to small vessel disease, but if you have chest pain, see your doctor to find out the cause. If you're having other signs and symptoms, such as shortness of breath, sweating, nausea, dizziness or pain that radiates beyond your chest to one or both of your arms or your neck — seek emergency medical care immediately.
- Lanza GA, et al. Primary coronary microvascular dysfunction: Clinical presentation, pathophysiology, and management. Circulation. 2010;121:2317.
- What is coronary microvascular disease? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/cmd/cmd_all.html. Accessed July 10, 2010.
- Beltrame JF, et al. Advances in coronary microvascular dysfunction. Heart, Lung and Circulation. 2009;18:19.
- Camici PC, et al. Coronary microvascular dysfunction. New England Journal of Medicine. 2007;356:830.
- Lakhani K, et al. Microvascular dysfunction in women with polycystic ovary syndrome. Human Reproduction. 2005;20:3219.
- Topcu S, et al. Metformin therapy improves coronary microvascular function in patients with polycystic ovary syndrome and insulin resistance. Clinical Endocrinology. 2006;65:75.
- Foster W, et al. Inflammation and microvascular and macrovascular endothelial dysfunction in rheumatoid arthritis: Effect of treatment. The Journal of Rheumatology. 2010;37:711.
- Kurth T, et al. Migraine and ischaemic vascular events. Cephalalgia. 2007;27:965.
- Coenzyme Q10. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed July 11, 2010.
- Littarru GP, et al. Clinical aspects of coenzyme Q10: An update. Nutrition. 2010;26:250.
- Hamilton SJ, et al. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009;32:810.
- L-arginine. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed July 11, 2010.
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