SymptomsBy Mayo Clinic staff
Small vessel disease symptoms include:
- Chest pain, squeezing or discomfort
- Chest pain associated with discomfort in your left arm or jaw
- Chest pain that worsens with daily activities and at times of emotional stress
- Neck, shoulder, upper back or abdominal discomfort
- Shortness of breath
- Unusual fatigue
- A loss of energy
- Trouble sleeping
If you've been treated for coronary artery disease with angioplasty and stents and your signs and symptoms haven't gone away, you may also have small vessel disease.
When to see a doctor
If you're having chest pain along with other signs and symptoms — such as shortness of breath, sweating, nausea, dizziness, or pain that radiates beyond your chest to one or both of your arms or your neck — seek emergency medical care immediately.
If you're having symptoms such as fatigue and abdominal pain, it might be difficult to tell if your signs and symptoms are due to small vessel disease, but if you have chest pain, see your doctor to find out the cause.
- Bairey Merz CN, et al. Syndrome X and microvascular coronary dysfunction. Circulation. 2011;124:1477.
- What is coronary microvascular disease? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/cmd/cmd_all.html. Accessed March 5, 2013.
- Camici PC, et al. Coronary microvascular dysfunction. New England Journal of Medicine. 2007;356:830.
- Lanza GA, et al. Primary coronary microvascular dysfunction: Clinical presentation, pathophysiology, and management. Circulation. 2010;121:2317.
- Cholesterol. Mayo Medical Laboratories. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8320. Accessed March 5, 2013.
- Topcu S, et al. Metformin therapy improves coronary microvascular function in patients with polycystic ovary syndrome and insulin resistance. Clinical Endocrinology. 2006;65:75.
- Kothawade K, et al. Microvascular coronary dysfunction in women-pathophysiology, diagnosis, and management. Current Problems in Cardiology. 2011;36:291.
- Littarru GP, et al. Clinical aspects of coenzyme Q10: An update. Nutrition. 2010;26:250.
- Gao L, et al. Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221:311.
- Teede HJ, et al. Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy. Fertility and Sterility. 2010; 93:184.
- EndoPat overview. Endopat.com. http://endopat.com/Home_Page.html. Accessed March 19, 2013.
- Grogan M (expert opinion). Mayo Clinic, Rochester, Minn. March 18, 2013.