CausesBy Mayo Clinic staff
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Doctors aren't certain what causes spina bifida. As with many other problems, it appears to result from a combination of genetic and environmental risk factors, such as a family history of neural tube defects and folic acid deficiency.
- Spina bifida fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/spina_bifida/detail_spina_bifida.htm. Accessed June 28, 2011.
- Lightner DD. Spina Bifida. In: Ferri FF. Ferri's Clinical Advisor 2012: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2012. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-323-05611-3..00028-8--sc29020&isbn=978-0-323-05611-3&sid=1180550958&uniqId=266655520-3#4-u1.0-B978-0-323-05611-3..00028-8--sc29020
- Spina bifida. March of Dimes. http://www.marchofdimes.com/pnhec/4439_1224.asp. Accessed June 27, 2011.
- Sandler AD. Children with spina bifida: Key clinical issues. Pediatric Clinics of North America. 2010;57:879.
- Folic acid: Questions and Answers. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/folicacid/faqs.html. Accessed June 29, 2011.
- Spina bifida. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/spinabifida/facts.html. Accessed June 30, 2011.
- Hochberg L. Prenatal screening and diagnosis of neural tube defects. http://www.uptodate.com/home/index.html. Accessed June 30, 2011.
- Routine tests in pregnancy. American Congress of Obstetricians and Gynecologists. http://www.acog.org/publications/patient_education/bp133.cfm. Accessed June 30, 2011.
- Adzick NS, et al. A randomized trial of prenatal versus postnatal repair of myelomeningocele. New England Journal of Medicine. 2011;364:993.
- Surgery on fetus reduces complications of spina bifida. National Institutes of Health. http://www.nichd.nih.gov/news/releases/020911-MOMS.cfm?renderforprint=1. Accessed June 30, 2011.