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Selective serotonin reuptake inhibitors (SSRIs)

Safety concerns with selective serotonin reuptake inhibitors

SSRIs are relatively safe. However, there are some things you should think about before you take one of these antidepressants:

  • Antidepressants and pregnancy. Some antidepressants may harm your unborn child if you take them during pregnancy or while you're breast-feeding. Paxil in particular appears to increase the risk of birth defects, including heart and lung problems. If you're taking an antidepressant and you're considering getting pregnant, talk to your doctor or mental health provider about the possible dangers. Don't stop taking your medication without contacting your doctor first.
  • Drug interactions. When taking an antidepressant, be sure to tell your doctor about any other medications or supplements you're taking. Some antidepressants can cause dangerous reactions when combined with certain medications or herbal remedies.
  • Blood-thinning medications and SSRIs. Use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) or anticoagulants, such as warfarin (Coumadin), may increase the risk of bleeding when combined with a SSRIs.
  • Serotonin syndrome. Rarely, an SSRI can cause dangerously high levels of serotonin. This is known as serotonin syndrome. It most often occurs when two medications that raise serotonin are combined. These include other antidepressants, medications for certain health conditions and the herbal supplement St. John's wort. Signs and symptoms of serotonin syndrome include confusion, rapid or irregular heart rate, dilated pupils, fever, and unconsciousness. Seek immediate medical attention if you have any of these signs or symptoms.

Suicide risk and antidepressants

The Food and Drug Administration (FDA) requires that all antidepressants carry a warning that some children, adolescents and young adults may be at increased risk of suicide when taking antidepressants. Anyone taking an antidepressant should be watched closely for worsening depression or unusual behavior — especially in the first few weeks after starting an antidepressant. Keep in mind, antidepressants are more likely to reduce suicide risk in the long run by improving mood.

Stopping treatment with selective serotonin reuptake inhibitors

SSRIs aren't considered addictive. However, stopping treatment abruptly or missing several doses can cause withdrawal-like symptoms, including:

  • Nausea
  • Headache
  • Dizziness
  • Lethargy
  • Flu-like symptoms

This is sometimes called discontinuation syndrome. Talk to your doctor before stopping so that you can gradually taper off the medication.

Finding the right antidepressant

Each person may react differently to a particular antidepressant and may be more susceptible to particular side effects. Because of this, one antidepressant may work better for you than another.

Properties of one particular SSRI may make it a better choice than another for you. For example, if you have low energy, a more energizing SSRI — such as fluoxetine (Prozac) — may be beneficial. If you're anxious, an SSRI that may help ease anxiety — such as paroxetine (Paxil) — may be a good option. When choosing an antidepressant, your doctor will take into account your particular symptoms, what other health problems you have, what other medications you take and what has worked for you in the past. Sometimes a combination of antidepressants may be the best treatment choice.

Inherited traits play a role in how antidepressants affect you. In some cases, DNA tests such as cytochrome P450 (CYP450) tests may give clues as to whether an antidepressant is likely to ease symptoms or cause side effects. DNA testing isn't widely used yet, but is becoming more common.

It can take a long time to find the best treatment for depression. It takes several weeks or longer before an antidepressant is fully effective and for initial side effects to ease up. You may need to try several antidepressants before you find the right one, but hang in there. With patience, you and your doctor can find a medication that works well for you.

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References
  1. Schatzberg AF, et al. Antidepressants: Introduction. In: Schatzberg AF, et al. Manual of Clinical Psychopharmacology. 7th ed. Arlington, Va.: American Psychiatric Publishing; 2010. http://www.psychiatryonline.com/content.aspx?aID=600624. Accessed Oct. 5, 2010.
  2. Fava M, et al. Antidepressants. In: Stern TA, et al. Massachusetts General Hospital Comprehensive Clinical Psychiatry. Philadelphia, Pa.: Mosby; 2008. http://www.mdconsult.com/das/book/body/221513496-3/0/1657/421.html?tocnode=57543329&fromURL=421.html#4-u1.0-B978-0-323-04743-2..50045-7_1104. Accessed Oct. 5, 2010.
  3. Chew RH, et al. Selective serotonin reuptake inhibitors and mixed-action antidepressants. In: Chew RH, et al. What your patients need to know about psychiatric medications. 2nd ed. Washington, DC.: American Psychiatric Publishing; 2009.
  4. Bostwick JM. A generalist's guide to treating patients with depression with an emphasis on using side effects to tailor antidepressant therapy. Mayo Clinic Proceedings. 2010;85:538.
MH00066 Dec. 9, 2010

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