Stevens-Johnson syndrome

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Symptoms

By Mayo Clinic staff

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Image of Stevens-Johnson syndrome Stevens-Johnson syndrome

Signs and symptoms of Stevens-Johnson syndrome include:

  • Facial swelling
  • Tongue swelling
  • Hives
  • Skin pain
  • A red or purple skin rash that spreads within hours to days
  • Blisters on your skin and mucous membranes, especially in your mouth, nose and eyes
  • Shedding (sloughing) of your skin

If you have Stevens-Johnson syndrome, several days before the rash develops you may experience:

  • Fever
  • Sore throat
  • Cough
  • Burning eyes

When to see a doctor
Stevens-Johnson syndrome requires immediate medical attention. Seek emergency medical care if you experience any of the following signs or symptoms:

  • Unexplained widespread skin pain
  • Facial swelling
  • Blisters on your skin and mucous membranes
  • Hives
  • Tongue swelling
  • A red or purple skin rash that spreads
  • Shedding of your skin
Causes Definition
References
  1. Nirken MH, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: Clinical manifestations; pathogenesis; and diagnosis. http://www.uptodate.com/home/index.html. Accessed Dec. 13, 2010.
  2. High WA, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: Management, prognosis, and long-term sequelae. http://www.uptodate.com/home/index.html. Accessed Dec. 13, 2010.
  3. Evans J. Topical treatment protocol for Stevens-Johnson syndrome and toxic epidermal necrolysis. Journal of Wound Ostomy & Continence Nursing. 2009;36:509.
  4. Hazin R, et al. Derm diagnoses you can't afford to miss. The Journal of Family Practice. 2009;58:298.
  5. Knowles S, et al. Clinical risk management of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum. Dermatologic Therapy. 2009;22:441.
  6. Ward KE, et al. Severe adverse skin reactions to nonsteroidal anti-inflammatory drugs: A review of the literature. American Journal of Health-System Pharmacy. 2010;67:206.
  7. Usatine RP, et al. Dermatologic emergencies. American Family Physician. 2010;82:773.
DS00940 April 9, 2011

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