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Treatments and drugs
By Mayo Clinic staffLeft untreated, Sweet's syndrome not associated with a more serious condition may disappear on its own within one to three months. Medications can improve skin lesions and associated symptoms in just two or three days, with the worst of the lesions disappearing within one to four weeks. This is true even for malignancy-associated Sweet's syndrome, although treatment or remission of the associated cancer will help, too.
With or without treatment, the lesions rarely leave a mark or scar when they eventually disappear. Your doctor may advise continuing treatment because recurrence of the condition is common.
Medications
Systemic corticosteroids (prednisone or prednisolone) are generally very effective in treating Sweet's syndrome. You typically take these oral anti-inflammatory medications for about four to six weeks. Topical corticosteroids may be used to provide immediate relief of swelling.
Other first line medications your doctor may use include potassium iodide therapy, which you take as an oral tablet or as drops, and colchicine, which has anti-inflammatory properties. Follow your doctor's instructions exactly when taking these medications and be sure your doctor knows about any other medications you're taking, to avoid harmful drug interactions.
- Farhi D, et al. The neutrophilic dermatoses. Dermatology Nursing. 2008;20:274.
- Moschella SL. Neutrophilic dermatoses. http://www.uptodate.com/home/index.html/. Accessed April 5, 2010.
- Sweet's syndrome: A dermatologic condition associated with fever and frequently confused with an infectious process. In: Mandell GL, et al. Mandell, Douglas, and Bennet's Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2010. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-0-443-06839-3..00052-7--s0060&uniq=193269557&isbn=978-0-443-06839-3&sid=978680989#lpState=open&lpTab=contentsTab&content=4-u1.0-B978-0-443-06839-3..00052-7--s0060%3Bfrom%3Dtoc%3Btype%3DbookPage%3Bisbn%3D978-0-443-06839-3. Accessed April 5, 2010.
- Cohen PR. Sweet's syndrome — A comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet Journal of Rare Diseases. 2007;2:34.
- Franks AG Jr. Skin manifestations of internal disease. Medical Clinics of North America. 2009;93:1265.
- Colchicine: Drugdex Evaluations. Micromedex Healthcare Series. http://www.micromedex.com. Accessed April 5, 2010.
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