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Causes

By Mayo Clinic staff

The bacteria that cause tetanus, Clostridium tetani, are found in soil, dust and animal feces. When they enter a deep flesh wound, spores of the bacteria may produce a powerful toxin, tetanospasmin, which actively impairs your motor neurons, nerves that control your muscles. The effect of the toxin on your motor neurons can cause muscle stiffness and spasms — the major signs of tetanus.

Risk factors Symptoms
References
  1. Tetanus: Questions and answers. Immunization Action Coalition. http://www.immunize.org/catg.d/p4220.pdf. Accessed Jan. 31, 2013.
  2. Roush SW, et al. Manual for the Surveillance of Vaccine-Preventable Diseases. 4th ed. Atlanta, Ga.: Centers for Disease Control and Prevention; 2011. http://www.cdc.gov/vaccines/pubs/surv-manual/chpt16-tetanus.html. Accessed Jan. 31, 2013.
  3. Tetanus. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec14/ch178/ch178i.html. Accessed Jan. 13, 2013.
  4. Long SS, et al. Principles and Practice of Pediatric Infectious Diseases. 4th ed. St. Louis, Mo.: Elsevier Saunders; 2012. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-2702-9..00301-9&isbn=978-1-4377-2702-9&uniqId=399011628-4#4-u1.0-B978-1-4377-2702-9..00301-9. Accessed Jan. 24, 2013.
  5. Prevention and management of wound infection. World Health Organization. http://www.who.int/hac/techguidance/tools/Prevention%20and%20management%20of%20wound%20infection.pdf. Accessed Jan. 31, 2013.
  6. Diphtheria, tetanus & pertussis vaccines: What you need to know. Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-dtap.pdf. Accessed Feb. 1, 2013.
  7. Tetanus, diphtheria (Td) or tetanus, diphtheria, pertussis (Tdap) vaccine: What you need to know. Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-td-tdap.pdf. Accessed Feb. 1, 2013.
DS00227 April 24, 2013

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