Tests and diagnosisBy Mayo Clinic staff
You may find out you have thrombocytosis through one of the following tests:
- A routine blood test that shows a higher than normal platelet count.
- During a physical exam, when your doctor finds that your spleen is enlarged or you have signs or symptoms of an infection or another condition, your doctor orders a complete blood count (CBC) to determine your platelet count.
- A blood smear — a test in which a small amount of your blood is examined under a microscope — helps determine the condition of your platelets.
Because a number of conditions can cause a temporary rise in your platelet count, your doctor likely will repeat the blood tests to see if your platelet count remains high over time.
A normal range for platelets is 150,000 to 450,000 platelets per microliter of blood. If your blood count is above 500,000, your doctor will likely look for an underlying condition. In most cases, signs and symptoms of the underlying condition help guide the diagnosis. Your doctor may also:
- Check the level of iron in your blood
- Test for markers of inflammation
- Order genetic testing to help determine if you have a blood and bone marrow disorder
- Conduct a bone marrow aspiration and biopsy to collect and examine bone marrow tissue
- Tefferi A. Approach to the patient with thrombocytosis. http://www.uptodate.com/index. Accessed Aug. 8, 2012.
- What are thrombocythemia and thrombocytosis? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/thrm/. Accessed Aug. 8, 2012.
- Tchebiner JZ, et al. Diagnostic and prognostic value of thrombocytosis in admitted medical patients. American Journal of the Medical Sciences. 2011;342:395.
- Skoda RC. Thrombocytosis. Hematology. 2009:159. http://asheducationbook.hematologylibrary.org/content/2009/1.toc. Accessed Aug. 8, 2012.