- With Mayo Clinic endocrinologist
Todd B. Nippoldt, M.D.
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Todd B. Nippoldt, M.D.
Todd Nippoldt, M.D.
Dr. Todd Nippoldt is a board-certified specialist in internal medicine and endocrinology and metabolism. He has special expertise in the area of hormone disorders affecting the pituitary and adrenal glands as well as the testes and ovaries. He has been a member of the Mayo Clinic staff since 1988.
He's a consultant in the Division of Endocrinology, Metabolism and Nutrition and works with patients who have disorders of the hormone-producing glands. Common disorders include diabetes, thyroid problems, osteoporosis and elevated cholesterol levels.
He's also involved in andrology, the study of male hormonal disorders, male infertility and male sexual dysfunction, and is an assistant professor of medicine at College of Medicine, Mayo Clinic.
Dr. Nippoldt, a St. Paul, Minn., native, has also contributed to "Mayo Clinic Health Letter," the "Mayo Clinic Family Health Book" and a Mayo Clinic CD-ROM. He's a fellow in the American College of Physicians and a member of the American Society for Reproductive Medicine, the American Society of Andrology, The Endocrine Society, The Pituitary Society and the American Association of Clinical Endocrinologists.
"I have found that those patients who have gone to the Internet and obtained accurate medical information come to their appointment with me very well informed, and the discussions regarding the evaluation and management of their condition are very productive and satisfying," he says.
"The key, however, is obtaining accurate medical information. As a medical editor, I hope to be able to ensure that accurate, relevant and up-to-date information is available for patients and their families."
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Question
Thyroid peroxidase antibody test: What is it?
What is a thyroid peroxidase antibody test? Does it diagnose thyroid disease?
Answer
from Todd B. Nippoldt, M.D.
If you've been diagnosed with thyroid disease, your doctor may recommend a thyroid peroxidase (TPO) antibody test — in addition to other thyroid tests — to help determine the cause. TPO, an enzyme normally found in the thyroid gland, plays an important role in the production of thyroid hormones. A thyroid peroxidase test detects antibodies against TPO in the blood.
The presence of thyroid peroxidase antibodies in your blood suggests that the cause of thyroid disease is due to an autoimmune disorder such as Hashimoto's disease or Graves' disease. In autoimmune disorders, your immune system makes antibodies that mistakenly attack normal tissue. Antibodies that attack the thyroid gland cause inflammation and impaired function of the thyroid.
Your doctor may also order a thyroid peroxidase test if you are pregnant and have a thyroid disease such as Hashimoto's disease or Graves' disease. In such cases, the thyroid peroxidase test can help determine whether your baby is at risk of thyroid disease.
Some people without thyroid disease may have TPO antibodies. However, the presence of thyroid peroxidase antibodies may increase the risk of future thyroid disorders. If you have normal thyroid function with TPO antibodies, your doctor may recommend periodic checkups to watch for future thyroid problems.
- Thyroid antibodies. Lab Tests Online: American Association for Clinical Chemistry. www.labtestsonline.org/understanding/analytes/thyroid_antibodies/test.html. Accessed Feb. 18, 2010.
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