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Risk factors
By Mayo Clinic staffIn most cases, the exact cause of a congenital heart defect, such as tricuspid atresia, is unknown, but several factors may increase the risk of a baby being born with this condition:
- A mother who had German measles (rubella) or another viral illness during early pregnancy
- A parent who has a congenital heart defect
- Drinking too much alcohol during pregnancy
- A mother who has poorly controlled diabetes
- Use of some types of medications during pregnancy, such as the acne drug isotretinoin (Claravis, Sotret) and some anti-seizure medications
- The presence of Down syndrome, a genetic condition that results from an extra 21st chromosome
References
- Sondheimer HM, et al. Cardiovascular diseases. In: Hay WW Jr, et al. Current Diagnosis and Treatment: Pediatrics. 19th ed. New York, N.Y.: McGraw Hill; 2009. http://www.accessmedicine.com/content.aspx?aID=3402846. Accessed April 28, 2010.
- Single-ventricle defects. American Heart Association. http://www.americanheart.org/print_presenter.jhtml?identifier=11072. Accessed April 28, 2010.
- Harris IS, et al. Congenital heart disease in adults. In: Crawford MH. Current Diagnosis & Treatment: Cardiology. 3rd ed. New York, N.Y.: McGraw Hill; 2009 http://www.accessmedicine.com/content.aspx?aID=3649722. Accessed April 28, 2010.
- Keane JF, et al. Tricuspid atresia: Clinical manifestations. In: Keane JF, et al. Nadas' Pediatric Cardiology. Philadelphia, Pa.: Elsevier; 2006. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-1-4160-2390-6..50050-7--cesec5&uniq=198820213&isbn=978-1-4160-2390-6&sid=991370226. Accessed April 30, 2010.
- Congenital heart defects. March of Dimes. http://www.marchofdimes.com/professionals/14332_1212.asp. Accessed April 28, 2010.
- Tricuspid atresia. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec19/ch287/ch287i.html. Accessed April 28, 2010.
- Sittiwangkul R, et al. Outcomes of tricuspid atresia in the Fontan era. Annals of Thoracic Surgery. 2004;77:889.
- Berg C, et al. Prenatal diagnosis of tricuspid atresia: Intrauterine course and outcome. Ultrasound in Obstetrics and Gynecology. 2010;35:183.
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