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Definition
By Mayo Clinic staffTriple X syndrome is an abnormality of the chromosomes that affects about 1 in 1,000 females. Females normally have two X chromosomes, one from each parent. In triple X syndrome, a female has three X chromosomes — hence, the name.
Triple X syndrome usually results from an error in the formation of a mother's egg cell or a father's sperm cell. Sometimes, triple X syndrome occurs as a result of an error early in the embryo's development.
Many women with triple X syndrome have no symptoms or only mild symptoms. In other cases, symptoms may be more pronounced — possibly including developmental delays.
Treatment for triple X syndrome depends on which symptoms, if any, your daughter exhibits and their severity.
- Otter M, et al. Triple X syndrome: A review of the literature. European Journal of Human Genetics. 2010;18:265.
- Triple X syndrome. U.S. National Library of Medicine's Genetics Home Reference. http://ghr.nlm.nih.gov/condition/triple-x-syndrome. Accessed June 14, 2010.
- Tartaglia NR, et al. A review of trisomy X (47,XXX). Orphanet Journal of Rare Diseases. 2010;5:8.
- Lalatta F, et al. Triple X syndrome: Characteristics of 42 Italian girls and parental emotional response to prenatal diagnosis. European Journal of Pediatrics. In press. Accessed June 14, 2010.
- Zabel CA (expert opinion). Mayo Clinic, Rochester, Minn. July 6, 2010.
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